cis-bis(N-benzoyl-N ',N '-dibenzylthioureido) platinum(II): Synthesis, molecular structure and its interaction with human and bovine serum albumin

Author(s)

Correa, Rodrigo S. ; Oliveira, Katia M. ; Perez, Hiram ; Plutin, Ana M. ; Ramos, Raul ; Mocelo, Raul ; Castellano, Eduardo E. ; Batista, Alzir A.

• Document type: Journal article
• Source: ARABIAN JOURNAL OF CHEMISTRY; v. 12, n. 8, p. 9-pg., 2019-12-01.

Abstract

In this paper, the title compound was synthesized from N-benzoyl-N',N'-dibenzyl thiourea ligand and potassium tetrachloroplatinate(II), and its interaction with human (HSA) and bovine (BSA) serum albumin was evaluated. Also, the crystal structure was determined from single-crystal X-ray diffraction, confirming that the platinum atom is coordinated with two chelated N-benzoyl-N',N'-dibenzylthiourea ligands in a distorted square-planar geometry. In the solid state, Hirshfeld surface analysis emphasizes that the molecules are connected by non-classical C-H center dot center dot center dot C, C-H center dot center dot center dot S and H center dot center dot center dot H intermolecular contacts. These weak interactions can be mainly responsible due to complex-BSA and complex-HSA binding. The complex interacts differently with HSA and BSA such as observed by the binding constant, K-b, presenting values of around 10(5) M-1 and 10(4) M-1, respectively. Thermodynamic parameters (Delta G, Delta H and Delta S) suggest spontaneous interactions between complex and the proteins. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of King Saud University. (AU)

• FAPESP's process: 13/26559-4 - Structural modifications in biologically active Ru(II) complexes toward the design of new metallodrug candidates
• Grantee: Rodrigo de Souza Corrêa
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/04147-9 - Evaluation of anticancer properties of ruthenium(II)complexes containing lapachol and lawsone bioligands
• Grantee: Katia Mara de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate