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Platelets as a 'natural factory' for growth factor production that sustains normal (and pathological) cell biology

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Author(s):
Andrade, Sheila Siqueira ; de Sousa Faria, Alessandra Valeria ; Queluz, Dagmar de Paulo ; Ferreira-Halder, Carmen Verissima
Total Authors: 4
Document type: Journal article
Source: Biological Chemistry; v. 401, n. 4, p. 6-pg., 2020-04-01.
Abstract

Platelets have attracted substantial attention in the current decade owing to their unexpected pleiotropic properties and conflicted functions. In fact, platelets participate in both health (hemostasis) and disease (thrombotic diseases). Much of the plasticity of platelets comes from the fact that platelets are the reservoir and the 'natural factory' of growth factors (GFs), with pivotal functions in wound repair and tissue regeneration. By combining the platelets' plasticity and biotechnological processes, Platelnnove Biotechnology optimized the production of GFs in nanoparticle biointerfacing by platelet content, which opens an avenue of possibilities. (AU)

FAPESP's process: 16/14459-3 - Human platelet lysate: from discard to value products in cell therapy and advanced cell-based medicine
Grantee:Sheila Siqueira Andrade
Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
FAPESP's process: 17/26317-1 - InGrowth, biomimetic product developed by platelet bioactivation platform: applications in the veterinary and research and development areas
Grantee:Sheila Siqueira Andrade
Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE