| Full text | |
| Author(s): |
da Silveira, Gessica Domingos
;
Bressan, Lucas Panes
;
Schmidt, Marcella Emilia Petra
;
Dal Molin, Thais Ramos
;
Teixeira, Carlos Alberto
;
Poppi, Ronei Jesus
;
da Silva, Jose Alberto Fracassi
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Journal of Solid State Electrochemistry; v. 24, n. 8, p. 12-pg., 2020-04-06. |
| Abstract | |
Evaluation of electrochemical behavior of 5-type phosphodiesterase inhibitory drugs is of major concern since they have been added illegally as adulterants in dietary supplements. Then, for the first time, the solid-sate electrochemistry of sildenafil and tadalafil is described using voltammetry of immobilized microparticles (VIMP). An electrochemical cell was designed and printed in a fused deposition modeling (FDM)-based 3D printer for VIMP measurements. The 3D-printed cell designed with a distance of 5 mm between the working and reference electrode presented better voltammetric response and decrease in the uncompensated resistance of the electrochemical system. Cyclic and square wave voltammograms of the individual compounds were recorded in a paraffin-impregnated graphite electrode in contact with 0.01 mol L-1 H2SO4. The electrochemical oxidation/reduction products were characterized by Raman spectroscopy and scanning electron microscopy (SEM). Different voltammetric responses were detected for the solid compounds depending on the solubility of the parent compound and their products of oxidation/reduction. Moreover, significant crystal re-structuring was also observed after voltammetric scan of the solid compounds. Under optimized conditions, sildenafil and tadalafil could be electrochemical identified and distinguished in dietary supplements. (AU) | |
| FAPESP's process: | 18/06478-3 - Use of 3D Printing on the Fabrication of Microfluidic Devices |
| Grantee: | José Alberto Fracassi da Silva |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/13496-8 - CHARACTERIZATION OF SYNTHETIC DRUGS AS ADULTERANTS IN DIETARY SUPPLEMENTS: USE OF VOLTAMMETRY OF IMMOBILIZED MICROPARTICLES IN SOLID STATE AS ANALYTICAL METHODOLOGY |
| Grantee: | Géssica Domingos da Silveira |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis |
| Grantee: | Marco Aurelio Zezzi Arruda |
| Support Opportunities: | Research Projects - Thematic Grants |