| Full text | |
| Author(s): |
Germann, Juergen
;
Gouveia, Flavia Venetucci
;
Martinez, Raquel C. R.
;
Zanetti, Marcus Vinicius
;
de Souza Duran, Fabio Luis
;
Chaim-Avancini, Tiffany M.
;
Serpa, Mauricio H.
;
Chakravarty, M. Mallar
;
Devenyi, Gabriel A.
Total Authors: 9
|
| Document type: | Journal article |
| Source: | BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING; v. 5, n. 9, p. 7-pg., 2020-09-01. |
| Abstract | |
Studies of habenula (Hb) function and structure provided evidence of its involvement in psychiatric disorders, including schizophrenia and bipolar disorder. Previous studies using magnetic resonance imaging (manual/semi-automated segmentation) have reported conflicting results. Aiming to improve Hb segmentation reliability and the study of large datasets, we describe a fully automated protocol that was validated against manual segmentations and applied to 3 datasets (childhood/adolescence and adult bipolar disorder and schizophrenia). It achieved reliable Hb segmentation, providing robust volume estimations across a large age range and varying image acquisition parameters. Applying it to clinically relevant datasets, we found smaller Hb volumes in the adult bipolar disorder dataset and larger volumes in the adult schizophrenia dataset compared with healthy control subjects. There are indications that Hb volume in both groups shows deviating developmental trajectories early in life. This technique sets a precedent for future studies, as it allows for fast and reliable Hb segmentation and will be publicly available. (AU) | |
| FAPESP's process: | 09/14891-9 - Longitudinal study on the neuroprotective and neurotrophic effects of lithium in bipolar disorder: identification of cellular and molecular targets clinically relevant |
| Grantee: | Rodrigo Machado-Vieira |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 13/03905-4 - NEUROBIOLOGICAL DIFFERENCES BETWEEN TREATMENT-NAIVE PATIENTS WITH BIPOLAR DISORDER SUBTYPES I AND II |
| Grantee: | Marcus Vinicius Zanetti |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 10/18672-7 - SPECGENE: genetic association study between single nucleotide polymorphisms of GAD1 and reelin and magnetic ressonance spectroscopy in bipolar I |
| Grantee: | Ricardo Alberto Moreno |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/23796-2 - "Genetic association study between cognitive performance, polymorphisms of GAD1/Reelin and 3T magnetic ressonance spectroscopy of GABA/glutamate in bipolar I disorder and healthy controls" |
| Grantee: | Márcio Gerhardt Soeiro-de-Souza |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |