Blue light-promoted N-H insertion of amides, isatins, sulfonamides and imides into aryldiazoacetates: Synthesis of unnatural alpha-aryl amino acid derivatives

Advanced search

Search - Use quotation marks to get a more specific result

Index

Field of knowledge

Start date

Betweenand

Full text
Author(s):	Okada Jr, Celso Y. ; dos Santos, Caio Y. ; Jurberg, Igor D. Total Authors: 3
Document type:	Journal article
Source:	Tetrahedron; v. 76, n. 51, p. 10-pg., 2020-12-18.
Abstract
A photochemical protocol using blue light allows the N-H insertion of amides, isatins, sulfonamides and imides into aryldiazoacetates to afford the corresponding alpha-amino esters. This method is experimentally simple, inexpensive and tolerates numerous functional groups, thus allowing the straightforward preparation of a variety of alpha-aryl amino acid derivatives in good yields. (C) 2020 Published by Elsevier Ltd. (AU)

FAPESP's process:	17/24017-0 - Application of Isoxazolones in Organic Synthesis
Grantee:	Igor Dias Jurberg
Support Opportunities:	Regular Research Grants