|Support type:||Scholarships in Brazil - Scientific Initiation|
|Effective date (Start):||December 01, 2018|
|Effective date (End):||July 31, 2019|
|Field of knowledge:||Physical Sciences and Mathematics - Chemistry - Organic Chemistry|
|Principal Investigator:||Fernanda Amaral de Siqueira|
|Grantee:||Verônica Barros da Cunha|
|Home Institution:||Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil|
He proposed project aims to synthesize amides derived from the N-substituted phenylglycine and phenylalanine amino acids with the propargyl group. The synthesis is based on four reaction steps: addition-elimination electrophilic substitution amidation; Dynamic kinetic resolution (DKR), with initial test of Palladium catalysts, performed in an alkaline medium and in a hydrogen atmosphere; followed by alkylation (insertion of the propargyl group); and finally, a hydrolysis reaction of the amide. The proposed synthesis is an unpublished route in the literature and aims to the formation of compounds that have inhibitory activity of the MAO-B enzyme present in the central nervous system, in which it is an important therapeutic target for disorders characterized by a decline in neurotransmission dopaminergic including Parkinson's disease (PD).