The Impact of Gastric Bypass on Telomere Length and Shelterin Complex Gene Expression: 6 Months Prospective Study

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Welendorf, Caroline Rossi ; Nicoletti, Carolina Ferreira ; Noronha, Natalia Yumi ; Ferreira, Flavia Campos ; Wolf, Leticia Santana ; de Souza Pinhel, Marcela Augusta ; Pinhanelli, Vitor Caressato ; de Oliveira, Cristiana Cortes ; de Oliveira, Bruno Affonso Parenti ; dos Santos Martins, Luzania ; Junior, Wilson Salgado ; Nonino, Carla Barbosa

• Document type: Journal article
• Source: OBESITY SURGERY; v. 31, n. 6, p. 8-pg., 2021-03-18.

Abstract

BackgroundTelomeres are structures located at the ends of chromosomes associated with a protein complex, known as the shelterin complex. In individuals with obesity, excess adipose tissue plays a key role in inducing a chronic and systemic inflammatory state, which can cause TL shortening. In this context, bariatric surgery is one of the most effective treatment modalities in improving metabolic control.AimTherefore, the present study aimed to evaluate how a short postoperative period of gastric bypass affects TL and expression of POT1, TRF1 and TRF2 genes.MethodsForty-eight women submitted to RYGB were evaluated before and after 6 months of the surgical procedure. Anthropometric measures of body weight and height (BMI), abdominal circumference (AC), body composition, food intake and blood collection for biochemical evaluation, TL analysis (DNA), and gene expression (RNA) were collected at each moment.ResultsThere was a reduction of weight, BMI, AC, FM and FFM as well as of glycemia, total cholesterol, LDL-cholesterol, and triglycerides after gastric bypass. No difference in energy intake and macronutrients consumption was observed. There was no significant change in TL, but there was a significant increase of POT1 and TRF1 gene expression after surgery, while TRF2 expression did not change.ConclusionsDespite bariatric surgery is not capable of increasing telomere length in a short-term period, no reduction is observed; additionally, we found a correlation between serum triglycerides concentration and TL. The increase of POT1 and TRF1 gene expression may explain the maintenance of the TL after 6 months postoperative period. (AU)

• FAPESP's process: 18/08784-4 - Weight regain in the postoperative period of bariatric surgery: sociodemographic, clinical, nutritional and genetic contributions
• Grantee: Carla Barbosa Nonino
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health
• Grantee: Fernando Barbosa Júnior
• Support Opportunities: Research Projects - Thematic Grants