| Full text | |
| Author(s): Show less - |
Francis Ribeiro de Souza
[1]
;
Carlos E. Rochitte
[2]
;
Douglas Carli Silva
[3]
;
Barbara Sampaio
[4]
;
Marisa Passarelli
;
Marcelo R. dos Santos
;
Guilherme W. Fonseca
[7]
;
Antonio Carlos Battaglia Filho
[8]
;
Kelly Correa
[9]
;
Renata Margarida do Val
[10]
;
Maurício Yonamine
[11]
;
Rosa Maria R. Pereira
[12]
;
Carlos Eduardo Negrão
[13]
;
Roberto Kalil-Filho
;
Maria Janieire de Nazaré Nunes Alves
[15]
Total Authors: 15
|
| Affiliation: Show less - | [1] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[2] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[3] Universidade de São Paulo. Faculdade de Medicina - Brasil
[4] Instituto de Medicina Tropical de São Paulo - Brasil
[7] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[8] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[9] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[10] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[11] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas - Brasil
[12] Universidade de São Paulo. Faculdade de Medicina - Brasil
[13] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[15] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
Total Affiliations: 15
|
| Document type: | Journal article |
| Source: | Arquivos Brasileiros de Cardiologia; v. 120, n. 11 2023-11-20. |
| Abstract | |
Abstract Background Anabolic androgenic steroid (AAS) abuse has been associated with coronary artery disease (CAD). Pericoronary fat attenuation (pFA) is a marker of coronary inflammation, which is key in the atherosclerotic process. Objective To evaluate pFA and inflammatory profile in AAS users. Methods Twenty strength-trained AAS users (AASU), 20 AAS nonusers (AASNU), and 10 sedentary controls (SC) were evaluated. Coronary inflammation was evaluated by mean pericoronary fat attenuation (mPFA) in the right coronary artery (RCA), left anterior descending coronary artery (LAD), and left circumflex (LCx). Interleukin (IL)-1 (IL-1), IL-6, IL-10, and TNF-alpha were evaluated by optical density (OD) in a spectrophotometer with a 450 nm filter. P<0.05 indicated statistical significance. Results AASU had higher mPFA in the RCA (-65.87 [70.51-60.70] vs. -78.07 [83.66-72.87] vs.-78.46 [85.41-71.99] Hounsfield Units (HU), respectively, p<0.001) and mPFA in the LAD (-71.47 [76.40-66.61] vs. -79.32 [84.37-74.59] vs. -82.52 [88.44-75.81] HU, respectively, p=0.006) compared with AASNU and SC. mPFA in the LCx was not different between AASU, AASNU, and SC (-72.41 [77.17-70.37] vs. -80.13 [86.22-72.23] vs. -78.29 [80.63-72.29] HU, respectively, p=0.163). AASU compared with AASNU and SC, had higher IL-1, (0.975 [0.847-1.250] vs. 0.437 [0.311-0.565] vs. 0.530 [0.402-0.780] OD, respectively, p=0.002), IL-6 (1.195 [0.947-1.405] vs. 0.427 [0.377-0.577] vs. 0.605 [0.332-0.950] OD, p=0.005) and IL-10 (1.145 [0.920-1.292] vs. 0.477 [0.382-0.591] vs. 0.340 [0.316-0.560] OD, p<0.001). TNF-α was not different between the AASU, AASNU, and SC groups (0.520 [0.250-0.610] vs. 0.377 [0.261-0.548] vs. 0.350 [0.182-430]), respectively. Conclusion Compared with ASSNU and controls, AASU have higher mPFA and higher systemic inflammatory cytokines profile suggesting that AAS may induce coronary atherosclerosis through coronary and systemic inflammation. (AU) | |
| FAPESP's process: | 12/10527-3 - Impact of self-administrating anabolic androgenic on cardiovascular system |
| Grantee: | Maria Janieire de Nazaré Nunes Alves |
| Support Opportunities: | Regular Research Grants |