| Grant number: | 12/10527-3 |
| Support Opportunities: | Regular Research Grants |
| Duration: | April 01, 2014 - September 30, 2016 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal Investigator: | Maria Janieire de Nazaré Nunes Alves |
| Grantee: | Maria Janieire de Nazaré Nunes Alves |
| Host Institution: | Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| Associated researchers: | Carlos Eduardo Negrão ; Carlos Eduardo Rochitte ; Marisa Passarelli |
Abstract
Anabolic Androgenic Steroids (AAS) misuse in athletes accelerate muscle development, increasing strength and functional capacity. However, adverse effects on cardiovascular system such as increase in blood pressure, cardiac hypertrophy, changes in lipid metabolism and sudden death in young people with history of abuse of AAS has been observed. On the other hand, it is not clear the mechanisms involved in these changes. Objective: The aims of this study are to test in AAS users the followed hypothesis: 1. Besides the reduction of HDL-cholesterol will be observed, impairment on the functionality of HDL2 e HDL3; 2. Increased deposition of calcium; 3. And fibroses in the myocardial interstitial; 4. Left Ventricular Diastolic dysfunction; 5. Increased arterial stiffness and reduction on pulse wave velocity; 6. Alterations on spontaneous baroreflex control of the cardiac frequency and arterial pressure, as well as, in cardiac frequency variability. Methods: Fifty male will be separated in three groups: 1) Twenty subjects involved in strength training (80 to 90% of maximal strength) non AAS users (NAASU); 2) Twenty subjects self-administering AAS (AASU) for at least two years involved in strength training (80 to 90% of maximal strength); 3) Ten health sedentary subjects non as sedentary control (SC). Al subjects will participate in clinical evaluation, laboratorial tests and measurement of urinary anabolic substances. Body composition will be evaluated through dual energy x-ray absorptiometry (DEXA). Deposition of calcium, collagen and fibroses macroscopic and microscopic on myocardial intertitial will be evaluated through magnetic ressonance. In those subjects that calcium percentil of 50 or more be observed, coronary angiotomography will be made to diagnose the presence, degree and extention of the obstructive atherosclerosis in coronary. Arterial stifness and pulse wave velocity will be evaluated through Doppler of carotid and femoral artery. Spontaneous baroreflex control will be evaluated through hemodynamic measure, digital noninvasive, beat-by-beat and oscillations of cardiac frequency and arterial pressure. (AU)
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