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Impact of self-administrating anabolic androgenic on cardiovascular system

Abstract

Anabolic Androgenic Steroids (AAS) misuse in athletes accelerate muscle development, increasing strength and functional capacity. However, adverse effects on cardiovascular system such as increase in blood pressure, cardiac hypertrophy, changes in lipid metabolism and sudden death in young people with history of abuse of AAS has been observed. On the other hand, it is not clear the mechanisms involved in these changes. Objective: The aims of this study are to test in AAS users the followed hypothesis: 1. Besides the reduction of HDL-cholesterol will be observed, impairment on the functionality of HDL2 e HDL3; 2. Increased deposition of calcium; 3. And fibroses in the myocardial interstitial; 4. Left Ventricular Diastolic dysfunction; 5. Increased arterial stiffness and reduction on pulse wave velocity; 6. Alterations on spontaneous baroreflex control of the cardiac frequency and arterial pressure, as well as, in cardiac frequency variability. Methods: Fifty male will be separated in three groups: 1) Twenty subjects involved in strength training (80 to 90% of maximal strength) non AAS users (NAASU); 2) Twenty subjects self-administering AAS (AASU) for at least two years involved in strength training (80 to 90% of maximal strength); 3) Ten health sedentary subjects non as sedentary control (SC). Al subjects will participate in clinical evaluation, laboratorial tests and measurement of urinary anabolic substances. Body composition will be evaluated through dual energy x-ray absorptiometry (DEXA). Deposition of calcium, collagen and fibroses macroscopic and microscopic on myocardial intertitial will be evaluated through magnetic ressonance. In those subjects that calcium percentil of 50 or more be observed, coronary angiotomography will be made to diagnose the presence, degree and extention of the obstructive atherosclerosis in coronary. Arterial stifness and pulse wave velocity will be evaluated through Doppler of carotid and femoral artery. Spontaneous baroreflex control will be evaluated through hemodynamic measure, digital noninvasive, beat-by-beat and oscillations of cardiac frequency and arterial pressure. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, FRANCIS RIBEIRO; DOS SANTOS, MARCELO RODRIGUES; PORELLO, RAFAEL ARMANI; PEIXOTO DA FONSECA, GUILHERME WESLEY; CARRARI SAYEGH, ANA LUIZA; LIMA, THAIS PINHEIRO; FERREIRA, FABIANA DIAS; DE OLIVEIRA, TIAGO FRANCO; YONAMINE, MAURICIO; TAKAYAMA, LILIAM; RODRIGUES PEREIRA, ROSA MARIA; NEGRAO, CARLOS EDUARDO; PASSARELLI, MARISA; ROCHITTE, CARLOS EDUARDO; DE NAZARE NUNES ALVES, MARIA JANIEIRE. Diminished cholesterol efflux mediated by HDL and coronary artery disease in young male anabolic androgenic steroid users. ATHEROSCLEROSIS, v. 283, p. 100-105, APR 2019. Web of Science Citations: 1.
DE SOUZA, FRANCIS RIBEIRO; KLUSER SALES, ALLAN ROBSON; DOS SANTOS, MARCELO RODRIGUES; PORELLO, RAFAEL ARMANI; PEIXOTO DA FONSECA, GUILHERME WESLEY; CARRARI SAYEGH, ANA LUIZA; BATTAGLIA FILHO, ANTONIO CARLOS; RODRIGUES PEREIRA, ROSA MARIA; TAKAYAMA, LILIAM; DE OLIVEIRA, TIAGO FRANCO; YONAMINE, MAURICIO; NEGRAO, CARLOS EDUARDO; DE NAZARE NUNES ALVES, MARIA JANIEIRE. Retrograde and oscillatory shear rate in young anabolic androgenic steroid users. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v. 29, n. 3, p. 422-429, MAR 2019. Web of Science Citations: 2.
PORELLO, RAFAEL ARMANI; DOS SANTOS, MARCELO RODRIGUES; DE SOUZA, FRANCIS RIBEIRO; PEIXOTO DA FONSECA, GUILHERME WESLEY; CARRARI SAYEGH, ANA LUIZA; DE OLIVEIRA, TIAGO FRANCO; AKIHO, CESAR ABREU; YONAMINE, MAURICIO; RODRIGUES PEREIRA, ROSA MARIA; NEGRAO, CARLOS EDUARDO; DE NAZARE NUNES ALVES, MARIA-JANIEIRE. Neurovascular Response during Exercise and Mental Stress in Anabolic Steroid Users. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 50, n. 3, p. 596-602, MAR 2018. Web of Science Citations: 0.
DOS SANTOS, MARCELO R.; SAYEGH, ANA L. C.; ARMANI, RAFAEL; COSTA-HONG, VALERIA; DE SOUZA, FRANCIS R.; TOSCHI-DIAS, EDGAR; BORTOLOTTO, LUIZ A.; YONAMINE, MAURICIO; NEGRAO, CARLOS E.; ALVES, MARIA-JANIEIRE N. N. Resting spontaneous baroreflex sensitivity and cardiac autonomic control in anabolic androgenic steroid users. Clinics, v. 73, p. -, 2018. Web of Science Citations: 1.

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