| Full text | |
| Author(s): Show less - |
Stella Maris Firmino
[1]
;
Cássia da Luz Goulart
[2]
;
João Paulo Gregorio
[3]
;
Klaus Werner Wende
[4]
;
Fernanda Yuri Yuamoto
[5]
;
Lana Kummer
[6]
;
Emílio Martins Curcelli
[7]
;
Alessandro Domingues Heubel
[8]
;
Erika Zavaglia Kabbach
[9]
;
Polliana Batista Santos
[10]
;
Audrey Borghi-Silva
[11]
;
Renata Gonçalves Mendes
[12]
;
Ângela Mérice de Oliveira Leal
[13]
;
Meliza Goi Roscani
[14]
Total Authors: 14
|
| Affiliation: Show less - | [1] Universidade Federal de São Carlos - Brasil
[2] Universidade Federal de São Carlos - Brasil
[3] Universidade Federal de São Carlos - Brasil
[4] Universidade Federal de São Carlos - Brasil
[5] Universidade Federal de São Carlos - Brasil
[6] Universidade Federal de São Carlos - Brasil
[7] Universidade Federal de São Carlos - Brasil
[8] Universidade Federal de São Carlos - Brasil
[9] Universidade Federal de São Carlos - Brasil
[10] Universidade Federal de São Carlos - Brasil
[11] Universidade Federal de São Carlos - Brasil
[12] Universidade Federal de São Carlos - Brasil
[13] Universidade Federal de São Carlos - Brasil
[14] Universidade Federal de São Carlos - Brasil
Total Affiliations: 14
|
| Document type: | Journal article |
| Source: | Jornal Vascular Brasileiro; v. 22, 2023-12-11. |
| Abstract | |
Abstract Background Prediabetes (PD) is defined as impaired fasting glucose and/or impaired glucose tolerance (IGT) and may be associated with high risk of cardiovascular injury. It is recommended that PD patients be screened for signs of arterial stiffness and cardiovascular injury to reinforce therapeutic strategies. Objectives To identify pulse wave velocity values discriminative for arterial stiffness and cardiovascular injury in PD patients. Methods A cross-sectional study was conducted with PD (N=43) and normoglycemic (N=37) patients who underwent clinical evaluation, arterial stiffness assessment by carotid-femoral pulse wave velocity (cfPWV) using SphygmoCor, laboratory blood analysis, investigation of morphological and functional cardiac variables by transthoracic echocardiogram, and assessment of carotid intima-media-thickness (CIMT) by carotid ultrasonography. A statistical analysis was performed using SPSS software and values of p<0.05 were considered significant. Results A cfPWV cut-off value of 6.9 m/s was identified for IGT (Sensitivity [SE]: 74% and Specificity [SP]: 51%). Comparison of general data and risk factors between subsets with values above and below this cutoff value revealed higher rates of fasting glucose (p=0.02), obesity (p=0.03), dyslipidemia (p=0.004), early signs of left ventricle (p=0.017) and right ventricle (p=0.03) impaired diastolic function, and elevated CIMT in subjects with cfPWV ≥ 6.9m/s (p=0.04). Conclusions In PD patients, a cfPWV cutoff of 6.9 m/s was considered a discriminative value for arterial stiffness. These findings highlight the value of early investigation of cardiovascular injury and aggressive therapy strategies with good control of risk factors in PD. (AU) | |
| FAPESP's process: | 19/10011-6 - Comparison of cardiovascular function, functional capacity and quality of life of prediabetics and normoglycemic individuals |
| Grantee: | Fernanda Yuri Yuamoto |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 19/08945-0 - Comparison of endothelial and cardiovascular function between prediabetic and normoglycemic individuals |
| Grantee: | João Paulo Gregorio |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |