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Comparison of cardiovascular function, functional capacity and quality of life of prediabetics and normoglycemic individuals

Grant number: 19/10011-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2019
Effective date (End): November 30, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Meliza Goi Roscani
Grantee:Fernanda Yuri Yuamoto
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil


Diabetes Mellitus (DM) is a chronic metabolic disease with complications such as nephropathy, neuropathy, retinopathy and cardiovascular complications. Prediabetes is the condition in which the glycemic level is above normal but below the diagnostic criteria of DM2. Its importance is due to the fact that 70% of pre-diabetics will progress to DM2, according to the American Diabetes Association. Also, because these complications are already present in pre-diabetes. It is believed that these complications may lead to impaired cardiac and endothelial function and, consequently, quality of life. Objective: to verify for signs of early markers of left ventricular dysfunction, impairment of functional capacity and endothelial dysfunction in pre-diabetic patients and to correlate the findings with the degree of physical inactivity and quality of life. Methods: A cross-sectional clinical study, composed of composed of 100 patients, divided into two groups: norm glycemic control group (NGC, N=50) and pre-diabetic group (PDM, N=50). Patients will undergo clinical evaluation, transthoracic echocardiogram, carotid intima-media thickness, functional capacity assessment, SF-36 quality of life questionnaire and International Physical Activity Questionnaires - IPAQ. Statistical analysis will be performed with estimated sample calculation of 100 patients, with Chi-square test for comparison between groups of categorical variables and Student's T test for continuous variables. Pearson's test will be performed to evaluate association between variables. Expected results: early signs of left ventricular diastolic dysfunction and endothelial dysfunction are expected to be associated with impaired quality of life and a higher degree of physical inactivity. (AU)

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