Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components

Author(s)

Isadora Sousa de Oliveira ; Nicoly Malachize Alano-da-Silva ^[2] ; Isabela Gobbo Ferreira ^[3] ; Felipe Augusto Cerni ^[4] ; Jacqueline de Almeida Gonçalves Sachett ; Wuelton Marcelo Monteiro ; Manuela Berto Pucca ^[7] ; Eliane Candiani Arantes ^[8]

• Document type: Journal article
• Source: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 30, 2024-01-22.

Abstract

Abstract Tityus serrulatus scorpion is responsible for a significant number of envenomings in Brazil, ranging from mild to severe, and in some cases, leading to fatalities. While supportive care is the primary treatment modality, moderate and severe cases require antivenom administration despite potential limitations and adverse effects. The remarkable proliferation of T. serrulatus scorpions, attributed to their biology and asexual reproduction, contributes to a high incidence of envenomation. T. serrulatus scorpion venom predominantly consists of short proteins acting as neurotoxins (α and β), that primarily target ion channels. Nevertheless, high molecular weight compounds, including metalloproteases, serine proteases, phospholipases, and hyaluronidases, are also present in the venom. These compounds play a crucial role in envenomation, influencing the severity of symptoms and the spread of venom. This review endeavors to comprehensively understand the T. serrulatus scorpion venom by elucidating the primary high molecular weight compounds and exploring their potential contributions to envenomation. Understanding these compounds' mechanisms of action can aid in developing more effective treatments and prevention strategies, ultimately mitigating the impact of scorpion envenomation on public health in Brazil. (AU)

• FAPESP's process: 21/11547-7 - Characterization of high molecular mass components from Tityus serrulatus venom
• Grantee: Nicoly Malachize Alano da Silva
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 19/10173-6 - Production, modification and characterization of animal toxins with potential biotechnological application
• Grantee: Eliane Candiani Arantes Braga
• Support Opportunities: Regular Research Grants
• FAPESP's process: 22/08964-8 - Discovery of human monoclonal antibodies (scFv) with cross-reactivity and pH-dependent targeting metalloprotease from Bothrops spp.
• Grantee: Isadora Sousa de Oliveira
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 20/13176-3 - Human monoclonal antibodies (scFv) discovery with cross-reactivity and pH-dependent to metalloproteases from Bothrops spp
• Grantee: Isadora Sousa de Oliveira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/11936-3 - Center for Translational Science and Biopharmaceutical Development
• Grantee: Benedito Barraviera
• Support Opportunities: Research Grants - Science Centers for Development