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Center for Translational Science and Biopharmaceutical Development

Grant number: 21/11936-3
Support Opportunities:Research Grants - Science Centers for Development
Duration: January 01, 2023 - December 31, 2027
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Benedito Barraviera
Grantee:Benedito Barraviera
Host Institution: Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP). Centro Virtual de Toxinologia. Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Pesquisadores principais:
Carlos Roberto Prudencio ; Eliane Candiani Arantes Braga ; Rui Seabra Ferreira Junior ; Saulo Philipe Sebastião Guerra ; Vitor Marcelo Silveira Bueno Brandão de Oliveira
Associated researchers:Elizabeth Natal de Gaspari ; Ernesto Lopes Pinheiro Junior ; Felipe Augusto Cerni ; Jair Pereira da Cunha Junior ; Jair Ribeiro Chagas ; Jan Tytgat ; José Angelo Lauletta Lindoso ; Karla de Castro Figueiredo Bordon ; Liria Hiromi Okuda ; Manuela Berto Pucca ; Marco Antonio Stephano ; Paulo Eduardo Martins Ribolla ; Manish Bhalla ; Ramendra Pati Pandey ; Regina Maria Catarino ; Steve Peigneur
Associated grant(s):23/01083-9 - Prospection of bioactive peptides with antitumor activity isolated from scorpion venoms from the Brazilian Amazon, AP.R
23/01554-1 - Antibacterial and antiviral activity of melittin and its impact on the proteomic profile of Acinetobacter baumannii, Enterococcus faecium, Klebsiella pneumoniae, Zika Virus and SARS-CoV-2, AP.R
Associated scholarship(s):24/02846-9 - Assessment of solubility and stability of a recombinant serine protease from Crotalus durissus collilineatus in its PEGylated and non-PEGylated forms, BP.MS
24/07363-6 - Validation and standardization of quality control in the cryoprecipitate production process, BP.TT
24/03257-7 - Communication, Graphic Design and Platform Management, BP.TT
+ associated scholarships 24/00072-6 - Breaking the boundaries between the University and Society through Scientific Journalism: CTS-CEVAP Scientific Diffusion, BP.JC
23/00973-0 - Evaluation of in vitro response to treatment with Melittin from Apis mellifera venom in cancer stem cells of canine osteosarcoma, BP.MS
23/11311-9 - Expression and PEGylation of Ts15, an ±-KTx from Tityus serrulatus venom, and evaluation of its immunosuppressive action in a rheumatoid arthritis model, BP.PD
22/16060-1 - From mechanisms to biomarkers of envenoming by Brazilian snakes: a multicentric study for the development of strategies in diagnosis and monitoring, BP.DR
23/11264-0 - Production by heterologous expression on Pichia pastoris and evaluation of the efficacy of a vascular endothelial growth factor and a serineprotease from snake venom, for the production of a new biopolimer with adhesive capacity, BP.PD
23/08872-9 - Expression and characterization of single-chain variable fragments (scFv) intrinsically fluorescents for SARS-COV-2 detection., BP.PD
23/05461-8 - Science communication from the Center for Translational Science and Development of Biopharmaceuticals, BP.JC
22/05566-1 - Construction and selection of a library of scFv monoclonal antibodies against the SARS-CoV-2 spike protein by Phage Display technology, BP.DR - associated scholarships

Abstract

Technological advances are continually emerging to improve the discovery, rational modification, production and purification of biopharmaceuticals. The identification of different species of microorganisms from Brazilian biodiversity, using innovative strategies, should be carried out with a view to discovering alternative hosts for heterologous expression. The Center for the Study of Poisons and Poisonous Animals (CEVAP) - Translational Research Unit at UNESP - has been prospecting and developing candidate molecules for the production of biopharmaceuticals since its foundation. Two bioproducts named respectively "Fibrin Sealant" and "Antiapeptic Serum" were developed by our team and have already crossed the "Valley of Death", and are awaiting investments for phase III clinical research and subsequent registration with ANVISA for distribution in the System's network Health Service (SUS). To meet the last stage of phase III research, the product needs Good Manufacturing Practices. To overcome this challenge, the researchers submitted to the Ministry of Health the construction of the Pilot Batch Factory for Biopharmaceuticals for Clinical Research, the only one in Latin America, which was approved and tendered by UNESP in August 2021 at the amount of R$ 12,222,222.20 . This Factory-School will meet internal demands, from other research institutions in Brazil, as well as from abroad, as it will function as a CDMO (Contract Development and Manufacturing Organization). The Translational Science and Biopharmaceutical Development Center proposed in this project, in addition to continuing existing products, will develop and implement platforms for prototyping recombinant molecules for a new fibrin 2.0 sealant to improve its performance as a wound healing agent; to research and produce mono and polyclonal antibodies against Sars-Cov-2, and finally to implement a platform for serological diagnosis against COVID-19 based on recombinant antigens. Antibody production and serological diagnosis technologies can be transferred to meet other viral diseases given the versatility and applicability of the proposal. In order to make the project viable, the applicants based at UNESP (Headquarter Unit), USP and Biological Institutes, Adolfo Lutz and Emilio Ribas (Partner Institutions), in addition to collaborating foreign institutions will put their greatest efforts to achieve the established goals and implement the projects and proposed subprojects. We will also have the participation of visiting researchers from KU Leuven from Belgium, and SRM University Delhi-NCR from India. The economic and financial counterparts are respectively R$ 10,280,728.92 and R$ 25,808,341.92, in addition to the UNESP commitment to hire 3 researchers and 3 technicians in the amount of R$ 4,056,378.75 for the project period. FAPESP will be responsible for the total amount of R$ 9,780,662.81, including for equipment only R$ 89,052.00 (domestic) and U$ 89,277.14 (imported) - already included in the total value of the project. (AU)

Articles published in Pesquisa para Inovação FAPESP about research grant:
Startup develops alternative treatment for atopic dermatitis 
New research center aims to fill key gap for advancement of biotechnology in Brazil 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAVALCANTE, JOELITON S.; DE ALMEIDA, DENIS EMANUEL GARCIA; SANTOS-FILHO, NORIVAL A.; SARTIM, MARCO AURELIO; BALDO, AMANDA DE ALMEIDA; BRASILEIRO, LISELE; ALBUQUERQUE, POLIANNA L.; OLIVEIRA, SAMELLA S.; SACHETT, JACQUELINE ALMEIDA GONCALVES; MONTEIRO, WUELTON MARCELO; et al. Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 14, p. 26-pg., . (21/11936-3)
FERREIRA, ISABELA; OLIVEIRA, ISADORA; BORDON, KARLA; REIS, MOUZARLLEM; WIEZEL, GISELE; SANCHEZ, CAROLINE; SANTOS, LUISA; SANTOS-FILHO, NORIVAL; PUCCA, MANUELA; ANTUNES, LUSANIA; et al. Beyond Angiogenesis: The Multitasking Approach of the First PEGylated Vascular Endothelial Growth Factor (CdtVEGF) from Brazilian Rattlesnake Venom. TOXINS, v. 15, n. 8, p. 21-pg., . (20/13176-3, 21/11936-3, 17/00586-6, 19/10173-6)
CAVALCANTE, JOELITON DOS SANTOS; DE ALMEIDA, DENIS EMANUEL GARCIA; MORAES, MICAEL SAGGION; SANTOS, SOPHIA RIBEIRO; PINCINATO, PEDRO MORIEL; RICIOPO, PEDRO MARQUES; DE OLIVEIRA, LAIS LACERDA B.; MONTEIRO, WUELTON MARCELO; FERREIRA-JUNIOR, RUI SEABRA. Challenges and Opportunities in Clinical Diagnostic Routine of Envenomation Using Blood Plasma Proteomics. TOXINS, v. 15, n. 3, p. 17-pg., . (21/11936-3)
KEMPE, PAULA REGINA GELINSKI; DE CASTRO, MATEUS VIDIGAL; KHURIYEH, VICTOR CAMPOS; BARRAVIERA, BENEDITO; FERREIRA JR, RUI SEABRA; DE OLIVEIRA, ALEXANDRE LEITE RODRIGUES. Ultrastructural Evidence of Synapse Preservation and Axonal Regeneration Following Spinal Root Repair with Fibrin Biopolymer and Therapy with Dimethyl Fumarate. POLYMERS, v. 15, n. 15, p. 20-pg., . (18/05006-0, 21/11936-3, 16/25478-9, 18/25845-7)
BUENO, CLEUBER RODRIGO DE SOUZA; TONIN, MARIA CLARA CASSOLA; BUCHAIM, DANIELA VIEIRA; BARRAVIERA, BENEDITO; FERREIRA JR, RUI SEABRA; SANTOS, PAULO SERGIO DA SILVA; REIS, CARLOS HENRIQUE BERTONI; PASTORI, CLAUDIO MALDONADO; PEREIRA, ELIANA DE SOUZA BASTOS MAZUQUELI; NOGUEIRA, DAYANE MARIA BRAZ; et al. Morphofunctional Improvement of the Facial Nerve and Muscles with Repair Using Heterologous Fibrin Biopolymer and Photobiomodulation. PHARMACEUTICALS, v. 16, n. 5, p. 18-pg., . (21/11936-3)
OLIVEIRA, ISADORA; FERREIRA, ISABELA; JACOB, BEATRIZ; CARDENAS, KIARA; CERNI, FELIPE; BAIA-DA-SILVA, DJANE; ARANTES, ELIANE; MONTEIRO, WUELTON; PUCCA, MANUELA. Harnessing the Power of Venomous Animal-Derived Toxins against COVID-19. TOXINS, v. 15, n. 2, p. 12-pg., . (20/13176-3, 21/11936-3, 19/10173-6)
DA COSTA, HERNAN H. M.; BIELAVSKY, MONICA; ORTS, DIEGO J. B.; ARAUJO, SERGIO; ADRIANI, PATRICIA P.; NOGUEIRA, JULIANA S.; ASTRAY, RENATO M.; PANDEY, RAMENDRA P.; LANCELLOTTI, MARCELO; CUNHA-JUNIOR, JAIR P.; et al. Production of Recombinant Zika Virus Envelope Protein by Airlift Bioreactor as a New Subunit Vaccine Platform. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 18, p. 25-pg., . (22/07256-0, 21/11936-3, 17/50333-7)
ISADORA SOUSA DE OLIVEIRA; NICOLY MALACHIZE ALANO-DA-SILVA; ISABELA GOBBO FERREIRA; FELIPE AUGUSTO CERNI; JACQUELINE DE ALMEIDA GONÇALVES SACHETT; WUELTON MARCELO MONTEIRO; MANUELA BERTO PUCCA; ELIANE CANDIANI ARANTES. Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 30, . (19/10173-6, 21/11547-7, 22/08964-8, 21/11936-3, 20/13176-3)
GABRIELA DE OLIVEIRA ALMEIDA; ISADORA SOUSA DE OLIVEIRA; ELIANE CANDIANI ARANTES; SUELY VILELA SAMPAIO. Snake venom disintegrins update: insights about new findings. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 29, . (19/10173-6, 20/15670-5, 22/05554-3, 22/04804-6, 22/08964-8, 21/11936-3, 20/13176-3)

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