Effects of Calendula officinalis extract on liver histopathology, lipid profile, and oxidative stress in rats submitted to a diet rich in cholesterol and carbohydrates

Author(s):Show less -

Gleide Gatti Fontes ^[1] ; Rodrigo de Barros Freitas ^[2] ; Palloma Porto Almeida ^[3] ; Luciana Moreira Lima ^[4] ; Silvia Almeida Cardoso ^[5] ; Virginia Ramos Pizziolo ^[6] ; Ricardo Tabach ^[7] ; Almir Gonçalves Wanderley ^[8] ; Ricardo Mario Arida ^[9] ; Afonso Caricati-Neto ^[10] ; Murched Omar Taha ^[11] ; Camilo Amaro de Carvalho ^[12] ; Fernando Sabia Tallo ^[13] ; Francisco Sandro Menezes-Rodrigues ^[14]

Affiliation:Show less -

^[1] Universidade Federal de Juiz de Fora - Brasil

^[2] Universidade Santo Amaro. School Medicine - Brasil

^[3] Universidade do Estado do Rio de Janeiro - Brasil

^[4] Universidade Federal do Estado do Rio de Janeiro - Brasil

^[5] Universidade Federal de Viçosa - Brasil

^[6] Universidade Federal de Viçosa - Brasil

^[7] Universidade Federal de São Paulo - Brasil

^[8] Universidade Federal de São Paulo - Brasil

^[9] Universidade Federal de São Paulo - Brasil

^[10] Universidade Federal de São Paulo - Brasil

^[11] Universidade Federal de São Paulo - Brasil

^[12] Universidade Federal de Viçosa - Brasil

^[13] Universidade Federal de São Paulo - Brasil

^[14] Universidade Federal de São Paulo - Brasil

• Document type: Journal article
• Source: Acta Cirurgica Brasileira; v. 38, 2023-10-13.

Abstract

ABSTRACT Purpose: To evaluate the modulatory properties of Calendula officinalis L. (Asteraceae) (C. officinalis) extract on cafeteria diet-fed rats. Methods: A cafeteria diet was administered ad libitum for 45 days to induce dyslipidemia. Then, the rats were treated with the formulations containing C. officinalis in the doses of 50, 100, and 150 mg/kg or only with the vehicle formulation; the control group received a commercial ration. Results: The cafeteria diet decreased glutathione S-transferase activity and high-density lipoprotein plasmatic levels and damaged the hepatic architecture. The C. officinalis extract was able to reduce lipid infiltration in liver tissue and to modulate oxidative stress and lipid profile markers. Conclusions: The correlations between the variables suggest a pathological connection between oxidative stress markers and serum lipid profile. (AU)

• FAPESP's process: 17/25565-1 - New therapeutic approach of the Parkinson´s disease: Neuroprotection stimulated by pharmacological modulation of the intracellular signaling by Ca2+/cAMP/NO
• Grantee: Afonso Caricati Neto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 22/10696-1 - Study of morphophysiological changes in the brain of rats submitted to a physical exercise program throughout life and during aging
• Grantee: Ricardo Mario Arida
• Support Opportunities: Regular Research Grants