Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ENAM gene polymorphisms associated with dental anomalies in individuals with cleft lip and palate

Full text
Author(s):
Fernanda Veronese de Oliveira [1] ; Carlos Ferreira dos Santos [2] ; Thiago José Dionísio [3] ; Lucimara Teixeira das Neves ; Gisele da Silva Dalben [5] ; Eloá Cristina Passucci Ambrosio [6] ; Paula Karine Jorge [7] ; Maria Aparecida Andrade Moreira Machado [8] ; Thais Marchini Oliveira
Total Authors: 9
Affiliation:
[1] University of São Paulo. Bauru School of Dentistry. Department of Pediatric Dentistry, Orthodontics and Community Health - Brasil
[2] University of São Paulo. Bauru School of Dentistry. Department of Biological Sciences - Brasil
[3] University of São Paulo. Bauru School of Dentistry. Department of Biological Sciences - Brasil
[5] University of São Paulo. Hospital Rehabilitation Anomalies Craniofacial - Brasil
[6] University of São Paulo. Hospital Rehabilitation Anomalies Craniofacial - Brasil
[7] University of São Paulo. Hospital Rehabilitation Anomalies Craniofacial - Brasil
[8] University of São Paulo. Bauru School of Dentistry. Department of Pediatric Dentistry, Orthodontics and Community Health - Brasil
Total Affiliations: 9
Document type: Journal article
Source: Braz. J. Oral Sci.; v. 23, 2024-04-05.
Abstract

Aim This study aimed to investigate the occurrence of enamelin gene (ENAM) single nucleotide polymorphisms (SNP) and ENAM polymorphism association with dental anomalies (DA) in individuals with unilateral or bilateral cleft lip and palate (CLP). Methods Saliva samples were collected from 147 individuals aged between 6 and 15 years-old, both genders, and divided into 4 groups: Group 1 (G1) - CLP and DA; Group 2 (G2) - CLP without DA; Group 3 (G3) - without CLP with DA; Group 4 (G4) - without CLP and DA. The genomic DNA was extracted from saliva samples and the following ENAM SNPs markers were genotyped: rs3796703, rs3796704, rs3796705, rs7671281, rs2609428, and rs35951442. Fisher exact and Pearson’s Chi-square tests statistically analyzed the results (α=5%). Results Individuals without CLP with DA (Group 3 - 19.2%) showed statistically higher prevalence of SNP rs2609428 heterozygotes (p=0.006) than individuals with CLP and DA (Group 1 - 0%). Individuals without CLP (10%) exhibited statistically higher prevalence of mutated heterozygotes/homozygous (p=0.028) than in individuals with CLP (1.3%). Conclusion SNP rs2609428 marker of ENAM gene may be associated with dental anomalies in individuals without cleft lip and palate. (AU)

FAPESP's process: 08/08927-8 - Screening of mutation in the genes IRF6, MSX1 and PAX9 in subjects with cleft lip and palate and tooth agenesis
Grantee:Carlos Ferreira dos Santos
Support Opportunities: Regular Research Grants
FAPESP's process: 11/21190-7 - Screening for mutations and polymorphisms of candidate genes on dental malformations of patients with cleft lip and palate
Grantee:Fernanda Veronese de Oliveira
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 09/12233-4 - Genetic study of AMELX and ENAM gene mutations on dental malformations of patients with and without cleft lip and palate
Grantee:Thais Marchini de Oliveira Valarelli
Support Opportunities: Regular Research Grants