| Full text | |
| Author(s): |
Kostov, Konstantin G.
;
Barbosa, Ananias A.
;
do Nascimento, Fellype
;
Cardoso, Paulo F. G.
;
Almeida, Ana C. P. L.
;
Quade, Antje
;
Legendre, Daniel
;
Hein, Luiz R. O.
;
Silva, Diego M.
;
Koga-Ito, Cristiane Y.
Total Authors: 10
|
| Document type: | Journal article |
| Source: | POLYMERS; v. 16, n. 22, p. 17-pg., 2024-11-01. |
| Abstract | |
Tracheal stenosis (i.e., the abnormal narrowing of the trachea) can occur due to a variety of inflammatory and infectious processes as well as due to therapeutic procedures undertaken by the patient. The most common cause of tracheal obstruction in patients has been prolonged intubation. Depending on the extent of the stenosis and its exact location, the surgical insertion of a tracheal stent is the only option for addressing this issue. The Montgomery T-tube implant is a valuable tracheal stent made from medical-grade silicone that provides a functional airway while supporting the tracheal mucosa. However, its performance is subject to gradual deterioration due to biofilm colonization of the stent's inner wall, which may explain the discomfort claimed by many patients and clinical failures. Recently, cold atmospheric plasmas (CAPs) have emerged as an alternative technology to many conventional medical procedures, such as wound healing, skin treatment, decontamination of medical devices, etc. Here, we report on plasma-induced surface modification of the inner wall of a T-tube implant, considering future biomedical applications. To generate the plasma, we employed a cold atmospheric pressure plasma jet in gas helium, which was directly inserted into the T-tube implant. To assess the treatment uniformity, the degree of surface modification and its extension along the stent's inner wall was analyzed using different process parameters. (AU) | |
| FAPESP's process: | 21/02680-5 - Study of cold plasma jet operating in atmospheric pressure for biomedical applications |
| Grantee: | Diego Morais da Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 19/05856-7 - Use of low temperature atmospheric pressure plasma in dentistry: from laboratory bench to clinics |
| Grantee: | Cristiane Yumi Koga Ito |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 20/09481-5 - Applications of non-thermal atmospheric plasmas in Dentistry: from the bench to the clinic |
| Grantee: | Fellype do Nascimento |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 23/02436-2 - Study of cold atmospheric plasma plume formation and propagation of reactive oxygen species inside tracheal t-tube implant: possible effects of plasma antimicrobial activity |
| Grantee: | Diego Morais da Silva |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |