Infection-elicited microbiota promotes host adaptation to nutrient restriction

Author(s):Show less -

Siqueira, Mirian Krystel De ; Andrade-Oliveira, Vinicius ; Stacy, Apollo ; Guimaraes, Joao Pedro Torres ; Alberca-Custodio, Ricardo Wesley ; Castoldi, Angela ; Santos, Jaqueline Marques ; Davoli-Ferreira, Marcela ; Menezes-Silva, Luisa ; Turato, Walter Miguel ; Han, Seong-Ji ; Zaretsky, Arielle Glatman ; Hand, Timothy Wesley ; Camara, Niels Olsen Saraiva ; Russo, Momtchilo ; Jancar, Sonia ; da Fonseca, Denise Morais ; Belkaid, Yasmine

• Document type: Journal article
• Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; v. 120, n. 4, p. 8-pg., 2023-01-24.

Abstract

The microbiota performs multiple functions vital to host fitness, including defense against pathogens and adaptation to dietary changes. Yet, how environmental chal-lenges shape microbiota resilience to nutrient fluctuation remains largely unexplored. Here, we show that transient gut infection can optimize host metabolism toward the usage of carbohydrates. Following acute infection and clearance of the pathogen, mice gained more weight as a result of white adipose tissue expansion. Concomitantly, pre-viously infected mice exhibited enhanced carbohydrate (glucose) disposal and insulin sensitivity. This metabolic remodeling depended on alterations to the gut microbiota, with infection-elicited Betaproteobacteria being sufficient to enhance host carbohydrate metabolism. Further, infection-induced metabolic alteration protected mice against stunting in the context of limited nutrient availability. Together, these results propose that alterations to the microbiota imposed by acute infection may enhance host fitness and survival in the face of nutrient restriction, a phenomenon that may be adaptive in settings where both infection burden and food precarity are prevalent. (AU)

• FAPESP's process: 21/06881-5 - Gut-lung axis: understanding the immune dialogue between barrier tissues in the development of disease
• Grantee: Denise Morais da Fonseca
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 17/02298-8 - Analysis of lipid metabolism after immunological scar induced by acute gastrointestinal infection
• Grantee: Mirian Krystel de Siqueira
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/15981-0 - Effect of anti-inflammatory cholinergic pathway in the metabolic changes following high fat diets
• Grantee: Luísa Menezes Silva
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 15/25364-0 - Impact of infection-induced immunological scarring on the long-term host metabolic homeostasis
• Grantee: Denise Morais da Fonseca
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 18/00458-0 - Development of an experimental model of environmental Enteropathy
• Grantee: Jaqueline Marques Santos
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 16/08385-7 - Impact of infection-induced immunological scarring on the long-term host metabolic homeostasis
• Grantee: Denise Morais da Fonseca
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 18/14562-4 - Contribution of gut microbiota for the metabolic changes induced by acute infection with Yersinia pseudotuberculosis
• Grantee: Mirian Krystel de Siqueira
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• FAPESP's process: 17/14209-0 - The role of neuroimmune interactions in the development of the "immunological scar" after acute intestinal infection.
• Grantee: Marcela Davoli Ferreira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral