Antimalarial analysis of pharmaceutical formulations and biological samples by capillary electrophoresis: the state of the art and applications

Author(s)

de Souza, Jessica Cordeiro Queiroz ; Penna, Eduarda Alves ; Chellini, Paula Rocha ; de Oliveira, Marcone Augusto Leal

• Document type: Journal article
• Source: ANALYTICAL METHODS; v. 16, n. 34, p. 26-pg., 2024-08-15.

Abstract

Malaria is a serious public health problem, being an endemic disease in 84 countries, mainly in Africa. This review explores the application of capillary electrophoresis (CE) techniques for analyzing antimalarial drugs, highlighting methods from 2000 to 2023 for the analysis of pharmaceutical formulations and human biological samples. The versatility, selectivity, high efficiency, cost-effectiveness, and high analytical frequency of CE techniques have become attractive choices for pharmaceutical analysis, focusing on quality control and impurity analysis applications. The evolution of achiral and chiral electromigration methods has been described based on the features of each mode of separation: capillary zone electrophoresis (CZE), micellar electrokinetic chromatography, microemulsion electrokinetic chromatography, and capillary electrochromatography. As expected, CZE is reported in most articles owing to its compatibility with drug properties and separation mode. However, it is necessary to perform other separation modes for a few drugs that are present in neutral form. After exhaustive research using different databases and statistical analyses, 27 articles using CE techniques for antimalarial drug analysis were found and are mentioned in this review. The evolution of achiral and chiral capillary electrophoresis methods that have been applied in the analysis of antimalarial drugs in pharmaceutical formulations and human biological samples, covering the literature from 2000 to 2023. (AU)

• FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
• Grantee: Marco Aurelio Zezzi Arruda
• Support Opportunities: Research Projects - Thematic Grants