The effect of mindfulness on decision-making, inhibitory control, and impulsivity of substance use disorder in-treatment patients: A randomized clinical trial

Author(s)

Donate, Ana Paula Goncalves ; de Macedo, Elizeu Coutinho ; Bedendo, Andre ; Felix Junior, Itamar ; Gallo, Giovanna Goncalves ; Opaleye, Emerita Satiro ; Noto, Ana Regina

• Document type: Journal article
• Source: PLoS One; v. 18, n. 11, p. 17-pg., 2023-11-07.

Abstract

This study aimed to investigate the effects of Mindfulness-Based Relapse Prevention (MBRP) in decision-making, inhibitory control and impulsivity compared to Treatment as Usual (TAU) for individuals with Substance Use Disorders (SUD's) in Brazil. A randomized clinical trial was conducted with participants from a therapeutic community (n = 122). Decision-making (Iowa Gambling Task), impulsivity dimensions (UPPS-P Scale), and inhibitory control (Stroop Color-Word Test) were assessed before and after the MBRP 8-week intervention. GLM Multivariate analysis was used to evaluate the effects of MBRP on different impulsivity measures. The results showed that MBRP+TAU improved the general decision-making score (p = 0,008) compared to TAU. However, no significant effects were found in impulsivity dimensions and inhibitory control in individuals with SUDs in the therapeutic community. This study found improvement in decision-making in the total IGT score; however, no effect for self-reported impulsivity and inhibitory control among middle-aged patients after an 8-weeks intervention of MBRP protocol in an inpatient setting. It adds information to the subject, with implications and possible directions to be followed by the next clinical trials with patients with SUDs in treatment.Trial registration: EnsaiosClinicos.gov.br: RBR-6c9njc. (AU)

• FAPESP's process: 19/01767-0 - Effectiveness of mindfulness-based relapse prevention as an adjunct to the treatment of substance use disorder: a randomized controlled trial
• Grantee: Itamar José Félix Junior
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/19472-5 - Innovative interventions related to alcohol consumption problems in Brazil: search for new approaches aimed at an old public health issue
• Grantee: Ana Regina Noto
• Support Opportunities: Research Projects - Thematic Grants