| Full text | |
| Author(s): |
Reis-de-Oliveira, Guilherme
;
Carregari, Victor Corasolla
;
de Sousa, Gabriel Rodrigues dos Reis
;
Martins-de-Souza, Daniel
Total Authors: 4
|
| Document type: | Journal article |
| Source: | NATURE COMMUNICATIONS; v. 15, n. 1, p. 12-pg., 2024-08-02. |
| Abstract | |
Shotgun proteomics analysis presents multifaceted challenges, demanding diverse tool integration for insights. Addressing this complexity, OmicScope emerges as an innovative solution for quantitative proteomics data analysis. Engineered to handle various data formats, it performs data pre-processing - including joining replicates, normalization, data imputation - and conducts differential proteomics analysis for both static and longitudinal experimental designs. Empowered by Enrichr with over 224 databases, OmicScope performs Over Representation Analysis (ORA) and Gene Set Enrichment Analysis (GSEA). Additionally, its Nebula module facilitates meta-analysis from independent datasets, providing a systems biology approach for enriched insights. Complete with a data visualization toolkit and accessible as Python package and a web application, OmicScope democratizes proteomics analysis, offering an efficient and high-quality pipeline for researchers. Analysing shotgun proteomics data is challenging due to diverse research questions. Here, authors introduce OmicScope, a computational tool available via both programming language and web platform, designed to analyze and integrate complex omics data from differential proteomics to meta-analysis. (AU) | |
| FAPESP's process: | 17/25588-1 - From the basic understanding to clinical biomarkers to schizophrenia: a neuroproteomics-centered multidisciplinary study |
| Grantee: | Daniel Martins-de-Souza |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 23/04767-6 - Exploring protein post-translational modifications in schizophrenia postmortem brains |
| Grantee: | Victor Corasolla Carregari |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 18/01410-1 - Evaluating the effects of clozapine on immune system cells |
| Grantee: | Guilherme Reis-De-Oliveira |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 19/05155-9 - The role of the glycoproteome and phosphoproteome during neuronal differentiation in schizophrenia |
| Grantee: | Victor Corasolla Carregari |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |