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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress

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Author(s):
Granjeiro, Erica M. [1] ; Gomes, Felipe V. [2] ; Guimaraes, Francisco S. [2] ; Correa, Fernando M. A. [2] ; Resstel, Leonardo B. M. [2]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Physiol, Sch Med, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Pharmacol, Sch Med, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Pharmacology Biochemistry and Behavior; v. 99, n. 4, p. 743-748, OCT 2011.
Web of Science Citations: 19
Abstract

Systemic administration of cannabidiol (CBD), a non-psychotomimetic compound from Cannabis sativa, attenuates the cardiovascular and behavioral responses to restraint stress. Although the brain structures related to CBD effects are not entirely known, they could involve brainstem structures responsible for cardiovascular control. Therefore, to investigate this possibility the present study verified the effects of CBD (15.30 and 60 nmol) injected into the cisterna magna on the autonomic and behavioral changes induced by acute restraint stress. During exposure to restraint stress (1 h) there was a significant increase in mean arterial pressure (MAP) and heart rate (HR). Also, 24 h later the animals showed a decreased percentage of entries onto the open arms of the elevated plus-maze. These effects were attenuated by CBD (30 nmol). The drug had no effect on MAP and HR baseline values. These results indicate that intracisternal administration of CBD can attenuate autonomic responses to stress. However, since CBD decreased the anxiogenic consequences of restraint stress, it is possible that the drug is also acting on forebrain structures. (C) 2011 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 10/17343-0 - Evaluation of CBD effects on the molecular and behavioral changes induced by repeated treatment with MK-801
Grantee:Felipe Villela Gomes
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 07/03685-3 - Typical and atypical neurotransmitters in neuropsychiatric disorders
Grantee:Francisco Silveira Guimaraes
Support Opportunities: Research Projects - Thematic Grants