Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments

Author(s)

Bernardi, Daniela S. ^[1] ; Pereira, Tatiana A. ^[1] ; Maciel, Naira R. ^[1] ; Bortoloto, Josiane ^{[1, 2]} ; Viera, Gisely S. ^[1] ; Oliveira, Gustavo C. ^[1] ; Rocha-Filho, Pedro A. ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Ciencias Farmaceut, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo - Brazil

^[2] Univ Ribeirao Preto, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF NANOBIOTECHNOLOGY; v. 9, SEP 28 2011.
• Web of Science Citations: 92

Abstract

Background: Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries. Cosmetic industries use rice bran oil in sunscreen formulations, anti ageing products and in treatments for skin diseases. The aim of this study was to create rice bran oil nanoemulsions using low energy emulsification methods and to evaluate their physical stability, irritation potential and moisturising activity on volunteers with normal and diseased skin types. Results: The nanoemulsion developed by this phase diagram method was composed of 10% rice bran oil, 10% surfactants sorbitan oleate/PEG-30 castor oil, 0.05% antioxidant and 0.50% preservatives formulated in distilled water. The nanoemulsion was stable over the time course of this study. In vitro assays showed that this formulation has a low irritation potential, and when applied to human skin during in vivo studies, the nanoemulsion improved the skin's moisture and maintained normal skin pH values. Conclusion: The results of irritation potential studies and in vivo assessments indicate that this nanoemulsion has potential to be a useful tool to treat skin diseases, such as atopic dermatitis and psoriasis. (AU)

• FAPESP's process: 09/01922-3 - Development of nano-emulsions containing rice bean oil (Oriza sativa) for atopic dermatitis and psoriasis treatment
• Grantee: Daniela Spuri Bernardi
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 09/05774-9 - Development of nanoemulsion to cosmetic application containing rice oil (Oryza sativa) and additives
• Grantee: Gisely Spósito Vieira
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 08/10382-0 - Development of cosmetic multiple emulsions containing sunflower oil and sesame oil: studies of physicochemical stability
• Grantee: Naira Rezende Maciel
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 09/07817-7 - Dispersed systems used in cosmetic technology
• Grantee: Pedro Alves da Rocha Filho
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/09618-9 - Quantification of gamma-oryzanol in rice oil (Oryza sativa) from nanoemulsions
• Grantee: Josiane Bortoloto
• Support Opportunities: Scholarships in Brazil - Scientific Initiation