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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Iron deficiency anaemia and blood lead concentrations in Brazilian children

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Author(s):
Carvalho Rondo, Patricia Helen [1] ; Conde, Andreia [1] ; Souza, Miriam Coelho [2] ; Sakuma, Alice [3]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, SP - Brazil
[2] Methodist Univ, Fac Nutr, Piracicaba, SP - Brazil
[3] Adolfo Lutz Inst, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene; v. 105, n. 9, p. 525-530, SEP 2011.
Web of Science Citations: 6
Abstract

This study investigated the relationship between iron deficiency/iron deficiency anaemia, assessed by several parameters, and blood lead concentration in children. This cross-sectional study involved 384 Brazilian children, aged 2-11 years, who lived near a lead-manipulating industry. Complete blood counts were obtained by an automated cell counter. Serum iron, total iron binding capacity (TIBC) and ferritin were determined respectively, by colorimetric, turbidimetric methods and chemiluminescence. Blood lead was measured by atomic absorption spectrophotometry. The impact of several parameters for assessment of iron status (haemoglobin, serum iron, TIBC, transferrin saturation, ferritin, red cell indices and red cell distribution width) and variables (gender, age, mother's education, income, body mass index, iron intake, and distance from home to lead-manipulating industry) on blood lead concentration was determined by multiple linear regression. There were significant negative associations between blood lead and the distance from home to the lead-manipulating industry (P < 0.001), Hb (P = 0.019), and ferritin (P=0.023) (R(2)=0.14). Based on these results, further epidemiological studies are necessary to investigate the impact of interventions like iron supplementation or fortification, as an attempt to decrease blood lead in children. (C) 2011 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved. (AU)