"Characterization and stability of α-tocopherol loaded solid lipid nanoparticles formulated with different fully hydrogenated vegetable oils"

Author(s)

Stahl, Marcella Aparecida ; Luedtke, Fernanda Luisa ; Grimaldi, Renato ; Gigante, Mirna Lucia ; Ribeiro, Ana Paula Badan

• Document type: Journal article
• Source: Food Chemistry; v. 439, p. 9-pg., 2023-12-08.

Abstract

Solid lipid nanoparticles can be compatible with several bioactive compounds and confer a differentiated crystalline structure. This study aimed to produce alpha-tocopherol loaded solid lipid nanoparticles with fully hydrogenated oils and fats from palm oil, soybean oil, and crambe oil, by high-pressure homogenization, using lecithin as an emulsifier. After recrystallization of solid lipid nanoparticles, dispersions were evaluated until 60 days of storage for particle size, polydispersity index, zeta potential, microstructure, dispersion stability and alpha-tocopherol quantification. alpha-tocopherol loaded solid lipid nanoparticles showed particle sizes and zeta potential values considered adequate for this type of particle. Presence of alpha-tocopherol altered thermal behavior of the particles, leading to increased crystallinity, with no changes in polymorphism, when compared to the unloaded solid lipid nanoparticles. All alpha-tocopherol loaded solid lipid nanoparticles dispersions showed stability with no losses of alpha-tocopherol, indicating their potential as a carrier for this compound in fortified foods. (AU)

• FAPESP's process: 16/11261-8 - OILS, FATS AND NANOTECHNOLOGY:DEVELOPMENT OF SOLID LIPID NANOPARTICLES AND NANOSTRUCTURED LIPID CARRIERS FOR INCORPORTATION OF BIOACTIVE LIPOPHILIC COMPOUNDS
• Grantee: Ana Paula Badan Ribeiro
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/27354-3 - Architecture of colloidal delivery systems: what is the role of structure on the digestibility?
• Grantee: Rosiane Lopes da Cunha
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/03172-0 - Development of nanostructured lipid carriers for incorporation of lipophilic bioactive compounds
• Grantee: Fernanda Luisa Lüdtke
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/05176-6 - Evaluation of in vitro digestibility of nanostructured lipid carriers containing ²-carotene
• Grantee: Fernanda Luisa Lüdtke
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate