Antitrypanosomal activity of new alkoxyhydroperoxides formed by cycloaddition of ozone into allyl moiety of eugenol

Author(s)

Accioly Jr, Marcos ; Ribeiro, Fernanda S. ; Amaral, Maiara ; Levatti, Erica V. C. ; Tempone, Andre G. ; Lago, Joao Henrique G. ; Uemi, Miriam

• Document type: Journal article
• Source: Tetrahedron; v. 159, p. 6-pg., 2024-05-08.

Abstract

Eugenol, a natural phenylpropanoid found in several plants, was exposed to ozone atmosphere to afford three new alkoxyhydroperoxides and prevised homovanillin. The effect of these compounds against the protozoan parasite Trypanosoma cruzi resulted in EC 50 values ranging from 7.4 to 10.5 mu M, superior to the standard drug benznidazole (EC 50 = 18.7 mu M). Based on these results, it is possible to consider these compounds as scaffolds for the development of new drug candidates against Chagas disease. (AU)

• FAPESP's process: 23/12447-1 - Searching for specialized metabolites from Brazilian floristic biodiversity as drug candidates for neglected tropical diseases
• Grantee: João Henrique Ghilardi Lago
• Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants
• FAPESP's process: 14/14801-8 - Are oxysterols able to modify ubiquitin and inhibit the proteolytic pathway by blockage of the ubiquitin proteasome system?
• Grantee: Miriam Uemi
• Support Opportunities: Regular Research Grants