| Full text | |
| Author(s): |
Vardanega, Renata
;
Ludtke, Fernanda L.
;
Loureiro, Luis
;
Hijo, Ariel A. C. Toledo
;
Martins, Joana T.
;
Pinheiro, Ana C.
;
Vicente, Antonio A.
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Food Research International; v. 188, p. 12-pg., 2024-05-11. |
| Abstract | |
The emulsifying potential of a biocompatible ionic liquid (IL) to produce lipid -based nanosystems developed to enhance the bioaccessibility of cannabidiol (CBD) was investigated. The IL (cholinium oleate) was evaluated at concentrations of 1 % and 2 % to produce nanoemulsions (NE -IL) and nanostructured lipid carriers (NLC-IL) loaded with CBD. The IL concentration of 1 % demonstrated to be sufficient to produce both NE -IL and NLC-IL with excellent stability properties, entrapment efficiency superior to 99 %, and CBD retention rate of 100 % during the storage period evaluated (i.e. 28 days at 25 degrees C). The in vitro digestion evaluation demonstrated that the NLC-IL provided a higher stability to the CBD, while the NE -IL improved the CBD bioaccessibility, which was mainly related to the composition of the lipid matrices used to obtain each nanosystem. Finally, it was observed that the CBD cytotoxicity was reduced when the compound was entrapped into both nanosystems. (AU) | |
| FAPESP's process: | 19/18608-1 - Development and application of ionic liquids derived from bioactive and natural compounds as functional additives and nutraceuticals for the food industry |
| Grantee: | Ariel Antonio Campos Toledo Hijo |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 22/04614-2 - Digestion simulation of ionic liquid-based systems for the development of functional food additives |
| Grantee: | Ariel Antonio Campos Toledo Hijo |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |