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Myofibroma with Atypical Features can Mimic Low-Grade Myofibroblastic Sarcoma: Two Paediatric Cases

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Author(s):
Reyes, Magdalena Raquel Torres ; Martins, Karina Helen ; Posantes, Gabriela Esperanza Maradiaga ; Zelaya, Florence Juana Maria Cuadra ; Renderos, Sandra Guadalupe Gongora ; Leon, Jorge Esquiche
Total Authors: 6
Document type: Journal article
Source: INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY; v. N/A, p. 4-pg., 2024-06-25.
Abstract

Myofibroma is a rare benign mesenchymal tumor that frequently affects the pediatric population with a predilection for the head and neck region. About 10% of myofibroma cases, presenting atypical features, can be misinterpreted as low-grade myofibroblastic sarcoma (LGMS), with therapeutic and prognostic impact. Here, we report two pediatric cases of benign myofibroblastic tumors, one of them showing typical characteristics of myofibroma, the other was an atypical myofibroma, which initially mimicked low-grade myofibroblastic sarcoma. Atypical myofibromas, despite its distinctive characteristics, follow a benign course, similar with typical myofibroma. It is necessary to distinguish atypical myofibroma from low-grade myofibroblastic sarcoma and avoid unnecessary invasive therapy. (AU)

FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region.
Grantee:Jorge Esquiche León
Support Opportunities: Regular Research Grants
FAPESP's process: 22/12760-9 - Clinicopathological correlation of the immune system, cell differentiation, angiogenesis, lipid metabolism and transcriptionally active HPV in a large series of head and neck squamous cell carcinomas
Grantee:Jorge Esquiche León
Support Opportunities: Regular Research Grants