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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Postnatal growth and cardiometabolic profile in young adults born large for gestational age

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Author(s):
Espineira, Aniette Renom [1] ; Fernandes-Rosa, Fabio Luiz [1] ; Bueno, Ana Carolina [1] ; de Souza, Roberto Molina [1] ; Moreira, Ayrton Custodio [2] ; de Castro, Margaret [2] ; Barbieri, Marco Antonio [1] ; Bettiol, Heloisa [1] ; Antonini, Sonir Rauber [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pediat, BR-14091900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Internal Med, BR-14091900 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CLINICAL ENDOCRINOLOGY; v. 75, n. 3, p. 335-341, SEP 2011.
Web of Science Citations: 25
Abstract

Context The association between large for gestational age (LGA) phenotype, postnatal growth and cardiometabolic risk (CMR) in adult life remains unclear. The role of IGF1 genotype on LGA-related outcomes in adult life is unknown. Aim To assess the postnatal growth, IGF-I levels, CMR and the influence of the 737.738 IGF1 in adults born LGA. Subjects Case-control study (n = 515) nested in a population-based prospective cohort (n = 2063); 117 LGA and 398 gender-matched controls appropriate for gestational age (AGA) subjects. Methods Anthropometry was evaluated at birth, at 9-10 and at 23-25 years old. At the age of 23-25 years, blood pressure (BP), glycaemia, insulinaemia, homeostasis model assessment - insulin resistance, lipids, fibrinogen, and plasma IGF-I and 737.738 IGF1 polymorphism were assessed. Results Large for gestational age subjects remained heavier and taller than AGA at 9-10 and 23-25 years (P < 0.05); at 23-25 years, LGA had greater waist circumference (WC; P < 0.05) and higher BP (P < 0.05) than controls. Body proportionality at birth did not predict metabolic outcome. LGA subjects presenting catch-down of weight in childhood had lower body mass index (BMI; P = 0.001), lower WC (P < 0.05) and lower BP (P < 0.05) at 2325 years. 737.738 IGF-I genotype differed between groups (P < 0.001). Homozygosis for polymorphic alleles was associated with increased odds of LGA (OR: 3.2; 95% CI: 1.5-6.9), higher IGF-I (56.9 +/- 16.4 vs 37.7 +/- 16.0 nm; P < 0.01) and lower BP (114/68 vs 121/73 mmHg; P < 0.05). Conclusions Young adults born LGA presented higher BMI, WC and BP and appear to be at higher CMR risk than AGA subjects. The 737.738 IGF1 polymorphism appears to play a role on birth size and LGA-related metabolic outcomes. (AU)