Antifungal activity of cercosporamide produced by Phaeosphaeriaceae GV-1 against pathogenic fungi

Author(s)

Portes, R. G. ; Barreto, Thayna Lopes ; Kanemaru, Michel Yudi Shinkai ; Ishida, Kelly ; Bicas, Juliano Lemos

• Document type: Journal article
• Source: Brazilian Journal of Microbiology; v. 55, n. 1, p. 7-pg., 2023-12-18.

Abstract

Fungal infections affect millions of people worldwide, and the several cases are related to invasive infections, which is a problem mainly for immunocompromised people, such as transplant and cancer patients with high mortality and morbidity rates. In addition, the number of emerging and multidrug-resistant fungal species has increased in the last decade. The search for new antifungal compounds is necessary, due to the increase in cases of resistance and the toxicity of drugs used in fungal infection treatment. This work aimed to study the antifungal activity of cercosporamide produced by Phaeosphaeriaceae GV-1. Cercosporamide was tested against pathogenic fungi by determining the minimum inhibitory (MIC) and minimum fungicidal (MFC) concentrations, using the broth microdilution method. Cercosporamide showed antifungal activity in vitro against 13 of 16 strains of medical importance tested, with the most susceptible species being Candida tropicalis, with MIC and MFC of 15.6 mu g/mL. Thus, cercosporamide might be considered a promising therapeutic antifungal agent. (AU)

• FAPESP's process: 21/01279-5 - Investigation of new targets and antifungal molecules on Candida spp. and Cryptococcus spp.
• Grantee: Kelly Ishida
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/04229-6 - Investigation of the action mechanism and the antifungal effect of urease inhibitors on Cryptococcus spp.
• Grantee: Thayná Lopes Barreto
• Support Opportunities: Scholarships in Brazil - Doctorate