Clinicopathological Features of 26 Intraoral Polymorphous Adenocarcinomas from a Single Brazilian Institution

Author(s)

de Aquino, Sibele Nascimento ; de Caceres, Cinthia Veronica Bardalez Lopez ; Bezerra, Helen Kaline Farias ; de Paiva, Joao Paulo Goncalves ; Louredo, Brendo Vinicius Rodrigues ; Santos-Silva, Alan Roger ; Lopes, Marcio Ajudarte ; Vargas, Pablo Agustin

• Document type: Journal article
• Source: Head and Neck Pathology; v. 18, n. 1, p. 12-pg., 2024-07-03.

Abstract

PurposeThis study describes a large, well-documented case series of salivary gland polymorphous adenocarcinomas (PAC) from a single Brazilian center.MethodsDemographic data, clinical presentation, histopathological and immunohistochemical features from 26 cases of PAC were analyzed and discussed in detail.ResultsMost patients were females (n = 21), with a ratio of 1:4.2 (male: female) with a mean age of 58.8 years (ranging from 36 to 84 years). The most common clinical presentation was a fibrocollagenous, firm nodular lesion, with a mean size of 2.46 cm (ranging from 0.5 to 3 cm). Most lesions occurred on the palate (n = 16), followed by buccal mucosa (n = 3), upper lip (n = 3), buccal vestibule (n = 2) and alveolar ridge (n = 1). Histologically, various growth patterns were observed, including tubular, solid, cribriform, papillary, and cystic. Additionally, glomeruloid slit-like structures, mucous, and clear cells were noted. Surface papillary epithelial hyperplasia was observed in a few cases. Nine cases exhibited myxoid and collagenous areas, while two cases showed fusiform areas and another case demonstrated squamous differentiation. Clear cell predominance was noted in two cases, and peri- and intraneural invasion was seen in eight cases. Immunohistochemical analysis revealed positivity for S-100, p63 and CK7, and negativity for p40 in all cases. The Ki-67 proliferation index was markedly low in most cases, with a mean of 2.5%.ConclusionWe have provided a broad, detailed description of the clinical and microscopic features of PAC in a large, Brazilian cohort. These findings, in a resource-limited area, may be quite useful for establishing a proper diagnosis. (AU)

• FAPESP's process: 22/01257-4 - Disrupting tumor resistance through therapy targeting depletion of Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma patient-derived xenograft
• Grantee: Brendo Vinicius Rodrigues Louredo
• Support Opportunities: Scholarships in Brazil - Doctorate