| Full text | |
| Author(s): |
Nani, Joao Victor
;
Ushirohira, Juliana Mayumi
;
Bradshaw, Nicholas J.
;
Machado-de-Sousa, Joao Paulo
;
Hallak, Jaime Eduardo Cecilio
;
Hayashi, Mirian A. F.
Total Authors: 6
|
| Document type: | Journal article |
| Source: | Revista Brasileira de Psiquiatria; v. 46, p. 10-pg., 2024-01-01. |
| Abstract | |
Objective: To assess nuclear distribution element-like 1 (Ndel1) enzyme activity following acute administration of sodium nitroprusside (sNP) in a rodent model of schizophrenia (SCZ) and in a cohort of chronic SCZ patients. Methods: Ndel1 activity was measured following sNP infusions in spontaneously hypertensive rats (SHR) (2.5 or 5.0 mg/kg) and in a double-blind randomized trial with 15 SCZ patients (0.5 mg/kg/min). Patients were randomized into two groups (group I: n=7; group II: n=8), with one group receiving placebo and the other sNP in phase A. In phase B, the groups switched treatments. sNP was administered as an infusion of 0.5 mu g/kg/min, for 4 h, while placebo was a 5% glucose solution infused under the same conditions. The infusions were administered once weekly over 4 weeks. Psychopathology was assessed using the 18-item figure 5 (BPRS-18 - Bech's version) and the negative subscale of the Positive and Negative Syndrome Scale. Results: Ndel1 activity was significantly reduced after sNP infusion in SHR and in patients receiving sNP (t = 7.756, degrees of freedom [df] = 97, p <0.0001, d(cohen)=1.44) compared to placebo. Reduced Ndel1 activity from baseline to the end of infusion was only seen in patients after treatment with sNP. Conclusion: SCZ patients may benefit from adjunctive therapy with sNP and that the Ndel1 enzyme is a candidate biomarker of psychopathology in the disorder. Future research should look into the role of Ndel1 in SCZ and the potential effects of sNP and drugs with similar profiles of action in both animals and patients. (AU) | |
| FAPESP's process: | 19/09207-3 - Study of molecular and cellular mechanisms in mental disorders |
| Grantee: | João Victor Silva Nani |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 20/01107-7 - Study to optimize the use of crotamine as a theranostic in the therapy of human diseases: cancer, metabolic syndrome and renal dysfunction |
| Grantee: | Mirian Akemi Furuie Hayashi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 22/00527-8 - Enzymatic activity of oligopeptidases Ndel1 and/or ACE in plasma or blood serum of patients with Depression |
| Grantee: | Larissa Ribino Parra |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 17/02413-1 - Validation of crotamine as a biomarker and evaluation of its potential use in the therapy of human diseases |
| Grantee: | Mirian Akemi Furuie Hayashi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/08287-3 - Effect of crotamine on glucose uptake by brown adipose tissue: evaluation in an experimental model with 18FDG PET |
| Grantee: | Marcelo Tatit Sapienza |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 22/03297-3 - Exploring the molecular and cellular mechanism(s) underlying neurodevelopmental disorders: investigating the role(s) of Nuclear Distribution Element like-1 (Ndel1) |
| Grantee: | João Victor Silva Nani |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 19/13112-8 - Study of molecular and cellular mechanisms involved in mental disorders: clinical and animal models analysis |
| Grantee: | Mirian Akemi Furuie Hayashi |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/50891-1 - INCT 2014: Translational Medicine |
| Grantee: | Jaime Eduardo Cecilio Hallak |
| Support Opportunities: | Research Projects - Thematic Grants |