Tissue-specific roles of mitochondrial unfolded protein response during obesity

Author(s)

Carneiro, Fernanda S. ; Katashima, Carlos K. ; Dodge, Joshua D. ; Cintra, Dennys E. ; Pauli, Jose Rodrigo ; Da Silva, Adelino S. R. ; Ropelle, Eduardo R.

• Document type: Journal article
• Source: Obesity Reviews; v. 25, n. 9, p. 15-pg., 2024-06-16.

Abstract

Obesity is a worldwide multifactorial disease caused by an imbalance in energy metabolism, increasing adiposity, weight gain, and promoting related diseases such as diabetes, cardiovascular diseases, neurodegeneration, and cancer. Recent findings have reported that metabolic stress related to obesity induces a mitochondrial stress response called mitochondrial unfolded protein response (UPRmt), a quality control pathway that occurs in a nuclear DNA-mitochondria crosstalk, causing transduction of chaperones and proteases under stress conditions. The duality of UPRmt signaling, with both beneficial and detrimental effects, acts in different contexts depending on the tissue, cell type, and physiological states, affecting the mitochondrial function and efficiency and the metabolism homeostasis during obesity, which remains not fully clarified. Therefore, this review discusses the most recent findings regarding UPRmt signaling during obesity, bringing an overview of UPRmt across different metabolic tissues. (AU)

• FAPESP's process: 22/02350-8 - Effect of intermittent fasting on UPRmt in the hypothalamus of obese mice
• Grantee: Fernanda Silva Carneiro
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 21/04292-2 - Implications of interleukin-6 on UPRmt in the hypothalamus of obese mice
• Grantee: Carlos Kiyoshi Katashima
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/21709-4 - Implications of mitonuclear imbalance and UPRmt in hypothalamic neurons in the genesis of Obesity
• Grantee: Eduardo Rochete Ropelle
• Support Opportunities: Research Projects - Thematic Grants