Unsaturation of serine lipids modulating the interaction of a cytosporone with models of the external leaflet of tumorigenic cell membranes

Author(s)

Jaroque, Guilherme Nunez ; dos Santos, Augusto Leonardo ; Sartorelli, Patricia ; Caseli, Luciano

• Document type: Journal article
• Source: Chemistry and Physics of Lipids; v. 258, p. 8-pg., 2023-12-09.

Abstract

Cytosporone-B was isolated from fungi and incorporated in models of tumorigenic cell membranes using palmitoyloleoylglycerophosphoserine (POPS) and dipalmitoyl glycerophosphoserine (DPPS) lipids. While for DPPS, the compound condensed the monolayer and decreased the surface compressional modulus, it expanded and kept the compressional modulus for POPS. Hysteresis for compression-expansion cycles was more sensitive for POPS than for DPPS, while a high degree of destabilization was observed for POPS. As observed with infrared spectroscopy and Brewster angle microscopy, specific changes were selective regarding molecular organization and morphology. Atomic force microscopy for transferred monolayers as Langmuir-Blodgett films also confirmed such specificities. We believe these data can help understand the mechanism of action of bioactive drugs in lipid interfaces at the molecular level. (AU)

• FAPESP's process: 22/09202-4 - Metabolomic and genomic study of fungi aiming at obtaining bioactive substances
• Grantee: Patricia Sartorelli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 22/03736-7 - Nanostructured interfaces for the investigation of bioactive substances in cell membrane models and for the construction of optoelectronic devices
• Grantee: Luciano Caseli
• Support Opportunities: Regular Research Grants