Host metabolomic responses in recurrent P. vivax malaria

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Yakubu, Michael N. ; Mwangi, Victor I. ; Netto, Rebeca L. A. ; Alecrim, Maria G. C. ; Alves, Jessica R. S. ; Almeida, Anne C. G. ; Santos, Gabriel F. ; Lima, Gesiane S. ; Machado, Lucas S. ; Koolen, Hector H. F. ; Guimaraes, Tiago P. ; Chaves, Andrea R. ; Vaz, Boniek G. ; Monteiro, Wuelton M. ; Costa, Fabio T. M. ; Lacerda, Marcus V. G. ; Gardinassi, Luiz G. ; de Melo, Gisely C.

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 14, n. 1, p. 13-pg., 2024-03-27.

Abstract

Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Metabolites extracted from the plasma of P. vivax-infected patients were subjected to LC-MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate beta-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax. (AU)

• FAPESP's process: 23/01208-6 - Development of new tools for searching and validating molecular targets for therapy against Plasmodium vivax
• Grantee: Jéssica Rafaela dos Santos Alves
• Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
• FAPESP's process: 21/14014-0 - Comparative study of Plasmodium vivax niches with emphasis on bone marrow and peripheral blood and their roles in the infection and pathology of this parasite
• Grantee: Jéssica Rafaela dos Santos Alves
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/18611-7 - Development of new tools for search and validation of molecular targets for therapy against Plasmodium vivax
• Grantee: Fabio Trindade Maranhão Costa
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 21/04632-8 - MRC-FAPESP: defining the role of the hematopoietic parasite reservoir in Plasmodium vivax infection and pathology
• Grantee: Fabio Trindade Maranhão Costa
• Support Opportunities: Regular Research Grants