Integrated aerobic exercise with LDE-docetaxel treatment: a novel approach to combat prostate cancer progression

Author(s)

Veras, Allice Santos Cruz ; Batista, Victor Rogerio Garcia ; Correia, Rafael Ribeiro ; Tavares, Maria Eduarda de Almeida ; Rubira, Rafael Jesus Goncalves ; Tavares, Elaine Rufo ; Giometti, Ines Cristina ; Maranhao, Raul Cavalcante ; Teixeira, Giovana Rampazzo

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 14, n. 1, p. 16-pg., 2024-04-26.

Abstract

The variability in response to conventional prostate cancer (PC) therapies, coupled with the emergent issue of drug resistance, underscores the critical need for innovative treatment strategies. Aerobic physical exercise reduced incidence of several cancers, but the mechanism underlying these effects associated the nanoemulsion not fully understood. The application of a lipid nanoemulsion (LDE) delivery system for docetaxel (DTX), showing marked enhancement in therapeutic efficacy when combined with aerobic physical exercise. This novel intervention potentiates the antitumor activity of LDE-delivered DTX by augmenting nanoparticle internalization and inducing cell cycle arrest. Our findings reveal that this synergistic treatment not only significantly reduces prostate weight and mitigates adenocarcinoma proliferation but also attenuates anti-apoptotic BCL-2 protein expression. Concurrently, it elevates pro-apoptotic proteins and diminishes inflammatory markers. Metabolic profiling of the combined therapy group disclosed additional benefits, such as reduced lipid and plasma glucose levels. Collectively, our data illuminate the profound impact of integrating LDE-mediated DTX delivery with structured physical exercise, which together spearhead a dual-front assault on PC. This multimodal approach heralds a new paradigm in PC management, accentuating the promise of combined pharmacological and non-pharmacological interventions to elevate tumor suppressor protein activity and refine patient outcomes. (AU)

• FAPESP's process: 20/15324-0 - Effects of high intensity interval physical training (HIIT) on the histological, biochemical and molecular parameters of the urinary bladder of spontaneously hypertensive rats (SHR)
• Grantee: Victor Rogério Garcia Batista
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 20/16310-2 - Development of biotechnology applied to prostatic carcinomatosis with the use of Docetaxel chemotherapy care nanoparticles associated with aerobic physical training
• Grantee: Giovana Rampazzo Teixeira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/16166-9 - DEVELOPMENT OF BIOTECHNOLOGY APPLIED TO PROSTATIC CARCINOMA WITH THE USE OF DOCETAXEL CHEMOTHERAPY CHARACTERISTIC NANOPARTICLES ASSOCIATED WITH AEROBIC PHYSICAL TRAINING
• Grantee: Allice Santos Cruz Veras
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/14514-2 - Analysis of cancer cachexia associated with the treatment of drug-carrying nanoparticles of docetaxel and methotrexate in sprague-dawley rats submitted to aerobic physical training
• Grantee: Rafael Ribeiro Correia
• Support Opportunities: Scholarships in Brazil - Master