Clinical complications in envenoming by Apis honeybee stings: insights into mechanisms, diagnosis, and pharmacological interventions

Author(s)

Cavalcante, Joeliton S. ; Riciopo, Pedro Marques ; Pereira, Ana Flavia Marques ; Jeronimo, Bruna Cristina ; Angstmam, Davi Gomes ; Possas, Felipe Carvalhaes ; de Andrade Filho, Adebal ; Cerni, Felipe A. ; Pucca, Manuela B. ; Ferreira Junior, Rui Seabra

• Document type: Journal article
• Source: FRONTIERS IN IMMUNOLOGY; v. 15, p. 18-pg., 2024-09-18.

Abstract

Envenoming resulting from Apis honeybee stings pose a neglected public health concern, with clinical complications ranging from mild local reactions to severe systemic manifestations. This review explores the mechanisms underlying envenoming by honeybee sting, discusses diagnostic approaches, and reviews current pharmacological interventions. This section explores the diverse clinical presentations of honeybee envenoming, including allergic and non-allergic reactions, emphasizing the need for accurate diagnosis to guide appropriate medical management. Mechanistic insights into the honeybee venom's impact on physiological systems, including the immune and cardiovascular systems, are provided to enhance understanding of the complexities of honeybee sting envenoming. Additionally, the article evaluates emerging diagnostic technologies and therapeutic strategies, providing a critical analysis of their potential contributions to improved patient outcomes. This article aims to provide current knowledge for healthcare professionals to effectively manage honeybee sting envenoming, thereby improving patient care and treatment outcomes. (AU)

• FAPESP's process: 23/01554-1 - Antibacterial and antiviral activity of melittin and its impact on the proteomic profile of Acinetobacter baumannii, Enterococcus faecium, Klebsiella pneumoniae, Zika Virus and SARS-CoV-2
• Grantee: Rui Seabra Ferreira Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 23/09921-3 - Antibacterial and antiviral activity of melittin and its impact on the proteomic profile of Acinetobacter baumannii, Enterococcus faecium, Klebsiella pneumoniae, Zika virus and SARS-CoV-2
• Grantee: Ana Flávia Marques Pereira
• Support Opportunities: Scholarships in Brazil - Support Program for Fixating Young Doctors
• FAPESP's process: 21/11936-3 - Center for Translational Science and Biopharmaceutical Development
• Grantee: Benedito Barraviera
• Support Opportunities: Research Grants - Science Centers for Development
• FAPESP's process: 22/16060-1 - From mechanisms to biomarkers of envenoming by Brazilian snakes: a multicentric study for the development of strategies in diagnosis and monitoring
• Grantee: Joeliton dos Santos Cavalcante
• Support Opportunities: Scholarships in Brazil - Doctorate