Disperse Red 1 azo dye: Consequences of low-dose/low-concentration exposures in mice and zebrafish

Full text
Author(s):	Fernandes, Fabio Henrique ; Abe, Flavia Renata ; Gomes, Tamara Barbosa ; dos Santos, Cibele Borges ; Kempinas, Wilma De Grava ; Leite, Bianca Arruda ; de Oliveira, Danielle Palma ; Salvadori, Daisy Maria Favero Total Authors: 8
Document type:	Journal article
Source:	MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS; v. 900, p. 8-pg., 2024-11-01.
Abstract
Color Index Disperse Red 1 (DR1), an azo dye widely used in the textile industry and released into aquatic environments, is genotoxic in somatic cells, but little is known concerning its effects on the reproductive system or the early stages of embryonic development. We have assessed the effects on the spermatozoa of male mice following oral exposure to the dye, at low doses, for 14 days. Measured endpoints were DNA damage (comet assay), miRNA-34c levels, and sperm number, morphology, and motility. Exposure caused decreased miRNA-34c levels. We have also examined dye effects on zebrafish embryos and larvae, which included developmental impairment, altered glutathione transferase activity, and effects on reactive oxygen species and lipid peroxidation levels. (AU)

FAPESP's process:	14/50945-4 - INCT 2014: National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactivies
Grantee:	Maria Valnice Boldrin
Support Opportunities:	Research Projects - Thematic Grants