The interplay between extracellular NAMPT and inflammatory cytokines in preeclampsia

Author(s)

Nunes, Priscila Rezeck ; Pereira, Daniela Alves ; Passeti, Luis Fernando Pereira ; Gomes, Karina Braga ; Sandrim, Valeria Cristina ; Luizon, Marcelo Rizzatti

• Document type: Journal article
• Source: JOURNAL OF REPRODUCTIVE IMMUNOLOGY; v. 163, p. 9-pg., 2024-05-03.

Abstract

Preeclampsia (PE) is the major cause of maternal-fetal mortality and morbidity. Its pathophysiology is not elucidated, but there is evidence for the role of visfatin/nicotinamide phosphoribosyl transferase (NAMPT), mainly due to its relation to endothelial dysfunction, a hallmark of PE. However, there is heterogeneous data regarding visfatin/NAMPT in healthy pregnancy (HP) and PE. Therefore, we performed a search on MEDLINE/ PubMed using the terms "visfatin and preeclampsia" and "NAMPT and preeclampsia, and we selected 23 original articles: 12 articles reported increased levels in PE compared to HP, only four articles showed lower levels and eight articles did not find differences regarding visfatin/NAMPT in the groups studied. It is widely acknowledged that levels detected in plasma, serum, or placenta can be influenced by the size of the population and sample analyzed, as well as genetic factors. We further discussed the correlations of visfatin/NAMPT with clinical biomarkers in PE and inflammatory pathways. Considering the common inflammatory mechanisms between PE and visfatin/NAMPT, few studies have recently performed serum or plasma dosages. In conclusion, further studies are needed to highlight the potential role of visfatin/NAMPT in the pathophysiology of PE. This will provide comparative evidence to establish it as a biomarker for disease outcomes and treatment. (AU)

• FAPESP's process: 20/14610-9 - Evaluation of pharmacological and molecular inhibition of NLRP3 inflammasome and its consequences in an in vitro model of Preeclampsia
• Grantee: Priscila Rezeck Nunes
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/07230-8 - Arginase in preeclampsia: study of genetic polymorphism, circulating factors and in vitro assays
• Grantee: Valeria Cristina Sandrim
• Support Opportunities: Regular Research Grants