| Full text | |
| Author(s): |
Barbeiro, Camila Oliveira
;
Silveira, Heitor Albergoni
;
Barbeiro, Roberto Henrique
;
Martins, Karina Helen
;
Bufalino, Andreia
;
Chahud, Fernando
;
Leon, Jorge Esquiche
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Head and Neck Pathology; v. 18, n. 1, p. 4-pg., 2024-06-28. |
| Abstract | |
BackgroundPrevious studies have shown that at least a of intraoral eosinophilic ulcer is best classified as a CD30 + T-cell lymphoproliferative disorder (LPD), with histopathology reminiscent of lymphomatoid papulosis (LyP) of the skin. Microscopically, a mixed population of inflammatory cells, often including eosinophils and varying numbers of atypical lymphoid cells, frequently expressing CD30, is typical for LyP, whose clinicopathological spectrum includes type A, B, C, D, E, and LyP with DUSP22/IRF4 rearrangement. To date, about 27 intraoral LyP cases have been reported. Of them, 7 cases were diagnosed as LyP type C, which is frequently confused with anaplastic large cell lymphoma (ALCL) on histopathology.MethodsA 60-year-old male was referred for a one-month history of a tongue ulcer.ResultsMicroscopy showed numerous subepithelial atypical large lymphoid cells, which expressed CD4 (with partial loss of CD3, CD5, and CD7), CD8 (few cells), CD30 (about 50%, in non-diffuse pattern with size variability), TIA-1, and Ki-67 (85%), without staining for CD56, ALK, LMP1, and EBER1/2, concerning for a diagnosis of ALCL. However, after three weeks, the lesion completely healed.ConclusionWe present here a rare case of intraoral CD30+ T-cell LPD that we believe is the oral counterpart of cutaneous LyP type C. (AU) | |
| FAPESP's process: | 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region. |
| Grantee: | Jorge Esquiche León |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 22/12760-9 - Clinicopathological correlation of the immune system, cell differentiation, angiogenesis, lipid metabolism and transcriptionally active HPV in a large series of head and neck squamous cell carcinomas |
| Grantee: | Jorge Esquiche León |
| Support Opportunities: | Regular Research Grants |