Phenotyping cardiopulmonary exercise testing measures in heart failure with reduced ejection fraction: A comparison between Italy and Brazil

Author(s)

Goulart, Gassia da Luz ; Agostoni, Piergiuseppe ; Salvioni, Elisabetta ; Silva, Rebeca Nunes ; Bassi-Dibai, Daniela ; Roscani, Meliza Goi ; Arena, Ross ; Myers, Jonathan ; Borghi-Silva, Audrey

• Document type: Journal article
• Source: HEART & LUNG; v. 65, p. 5-pg., 2024-02-24.

Abstract

Background: While patients with heart failure (HF) with reduced left ventricular ejection fraction (HFrEF) constitutes a global health crisis the incidence, prevalence and prognosis of the disease may differ depending on the continent and country. Objective: To profile, analyze and compare cardiopulmonary exercise testing (CPET) data of patients with HFrEF between Italian and Brazilian cohorts. Methods: In this observational study, a total of 630 patients with clinical and functional diagnosis of HFrEF (315 patients from Brazil and 315 patients from Italy) performed CPET. Results: Although Brazilian patients were slightly younger (Brazil 60 +/- 10 vs Italy 64 +/- 11 p<0.001) with a better peak oxygen consumption (VO2), circulatory power and left ventricular ejection fraction (LVEF) (p<0.01), ventilatory inefficiency and oscillation ventilation was higher when compared to the Italian cohort. When stratifying patients with LVEF <= 30 % and age >= 60 years, Brazilian patients presented worse ventilatory efficiency, and lower peak VO2 compared to the Italian cohort. Conclusion: Patients with HFrEF from Brazil exhibited higher ventilatory inefficiency and a greater prevalence of oscillatory ventilation during CPET compared to patients with the same diagnosis from Italy. (AU)

• FAPESP's process: 20/13465-5 - Identification of prognostic variables from the cardiopulmonary exercise test to stratify Heart Failure severity
• Grantee: Cássia da Luz Goulart
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• FAPESP's process: 18/03233-0 - Study of cardiorespiratory interaction and the supply of peripheral and cerebral oxygen as modulators of exercise capacity during bilevel application in the coexistence of COPD-CHF
• Grantee: Cássia da Luz Goulart
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)