Impact of combined exercise on diastolic function and inflammatory response in patients with heart failure and reduced ejection fraction

• Grant number: 15/00275-5
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2015
• End date: July 31, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Meliza Goi Roscani
• Grantee: Meliza Goi Roscani
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated researchers: Ângela Merice de Oliveira Leal ; Aparecida Maria Catai ; Beatriz Bojikian Matsubara ; João Carlos Hueb ; Jonas Alves de Araujo Junior ; Maria Terezinha Serrão Peraçoli ; Silméia Garcia Zanati Bazan

Abstract

The exercise improves quality of life and functional capacity of patients with heart failure (HF) with reduced or preserved ejection fraction (LVEF). The beneficial effects of exercise are not due to improvement in LVEF. On the other hand, some studies have pointed the beneficial effects of physical activity on diastolic function and inflammatory response. Given the importance of LV filling pressure in patients with symptoms of HF, it is suspected that the benefits of exercise in these patients are associated with better LV diastolic performance. Objectives: To evaluate the combined effect of physical exercise on diastolic function and inflammatory response in patients with HF and reduced LVEF and investigate whether the improvement in diastolic function is an important factor in improving symptoms, functional capacity and quality of life of these patients. Methodology: A prospective longitudinal will be performed in patients with HF and a LVEF less than 50%. Two groups are matched by age and sex. Intervention group: patients who underwent 12 weeks of combined and supervised exercise, 3 times per week. The control group did not undergo the practice of exercise. Both groups will undergo, before and after the protocol, echocardiogram, walk test, quality of life questionnaire and inflammatory biomarkers' analysis. Statistical analysis of repeated measures ANOVA will be performed to compare the clinical and ultrasound before and after the intervention. For comparison between groups will be held, t test and simple linear regression. Expected Results: We hope to find improvement in diastolic function and inflammatory response in patients undergoing exercise program. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FABRI, TAINA; CATAI, APARECIDA MARIA; RIBEIRO, FABIO H. O.; ARAUJO JUNIOR, JONAS A.; MILAN-MATTOS, JULIANA; ROSSI, DANIELLE A. A.; CONEGLIAN, REGINA C.; BORRA, RICARDO C.; ZANATI BAZAN, SILMEIA GARCIA; HUEB, JOAO CARLOS; et al. Impact of a Supervised Twelve-Week Combined Physical Training Program in Heart Failure Patients: A Randomized Trial. CARDIOLOGY RESEARCH AND PRACTICE, v. 2019, SEP 3 2019. (15/00275-5)

ROSCANI, MELIZA GOI; DUARTE, JULIANA DA CUNHA; AUGUSTO, GUSTAVO NICOLODI; DE MORAES SALGUEIRO, THAYSA RODRIGUES; MEIRELES, MARIANA N.; GOBBI, JULIANA I. F.; OKOSHI, KATASHI; HUEB, JOAO CARLOS. Association Between Left Ventricle Diastolic Dysfunction and Unfavorable Prognostic Markers in Patients with Aortic Insufficiency. JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, v. 11, n. 6, p. OC09-OC11, JUN 2017. (15/00275-5)

ROSCANI, M. G.; FABRI, T.; CATAI, A. M.; RIBEIRO, F. H. O.; ARAUJO, J. A., JR.; MATTOS, J. M.; ROSSI, D. A. A.; BORRA, R. C.; BAZAN, S. G. Z.; PERACOLI, M. T. S.; et al. The role of diastolic function in the quality of life and functional capacity of patients with heart failure undergoing a combined exercise program. EUROPEAN JOURNAL OF HEART FAILURE, v. 19, p. 1-pg., 2017-05-01. (13/24607-1, 15/00275-5)