In Vivo Antigenotoxicity of Baccharin, an Important Constituent of Baccharis dracunculifolia DC (Asteraceae)

Author(s)

Oliveira, Pollyanna F. ^[1] ; Monteiro Neto, Moaeir A. B. ^[1] ; Leandro, Luis F. ^[1] ; Bastos, Jairo K. ^[2] ; da Silva Filho, Ademar A. ^[3] ; Tavares, Denise C. ^[1]

Affiliation

^[1] Univ Franca, BR-14404600 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, BR-05508 Sao Paulo - Brazil

^[3] Univ Fed Juiz de Fora, Fac Pharm, Juiz De Fora, MG - Brazil

• Document type: Journal article
• Source: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY; v. 109, n. 1, p. 35-41, JUL 2011.
• Web of Science Citations: 5

Abstract

Baccharin (3-prenyl-4-(dihydrocinnamoyloxy)cinnamic acid) is an important chemical compound isolated from the aerial parts of Baccharis dracunculifolia DC (Asteraceae), a native plant of South America, and the most important plant source of Brazilian green propolis. The present study was designed to investigate the ability of baccharin to modulate the genotoxic effects induced by doxorubicin and methyl methanesulphonate in male Swiss mice using the micronucleus and comet assays, respectively. The different doses of baccharin {[}0.12, 0.24 and 0.48 mg/kg body-weight (b.w.)] were administered simultaneously to doxorubicin (micronucleus test; 15 mg/kg b.w.) and to methyl methanesulphonate (comet assay; 40 mg/kg b.w.). The results showed a significant decrease in the frequency of micronucleated polychromatic erythrocytes in animals treated with baccharin and doxorubicin compared to animals that received only doxorubicin. This reduction ranged from 39.8% to 50.7% in the micronucleus test. The extent of DNA damage in liver cells was significantly lower in animals treated with different concentrations of baccharin combined with methyl methanesulphonate in comparison with the damage observed for animals treated only with methyl methanesulphonate. These differences resulted in a significant reduction in the extent of DNA damage, which ranged from 47.8% to 60.6%. (AU)

• FAPESP's process: 09/12019-2 - In vivo and in vitro evaluation of mutagenic/genotoxic and antimutagenic/antigenotoxic potential of baccharin, an important chemical compound of Baccharis dracunculifolia
• Grantee: Pollyanna Francielli de Oliveira
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 07/07211-6 - Study of mutagenic and/or antimutagenic activity of Baccharis dracunculifolia and Artepillin C in mammalian cells
• Grantee: Denise Crispim Tavares
• Support Opportunities: Regular Research Grants