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Mapping Thrombosis Serum Markers by 1H-NMR Allied with Machine Learning Tools

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Martins, Lucas G. ; Manzini, Bruna M. ; Montalvao, Silmara ; Honorato, Millene A. ; Colella, Marina P. ; Hayakawa, Gabriela G. Y. ; de Paula, Erich V. ; Orsi, Fernanda A. ; Braga, Erik S. ; Avramovic, Natasa ; Omage, Folurunsho Bright ; Tasic, Ljubica ; Annichino-Bizzacchi, Joyce M.
Total Authors: 13
Document type: Journal article
Source: Molecules; v. 29, n. 24, p. 15-pg., 2024-12-01.
Abstract

Machine learning and artificial intelligence tools were used to investigate the discriminatory potential of blood serum metabolites for thromboembolism and antiphospholipid syndrome (APS). 1H-NMR-based metabonomics data of the serum samples of patients with arterial or venous thromboembolism (VTE) without APS (n = 32), thrombotic primary APS patients (APS, n = 32), and healthy controls (HCs) (n = 32) were investigated. Unique metabolic profiles between VTE and HCs, APS and HCs, and between VTE and triple-positive APS groups were indicative of the significant alterations in the metabolic pathways of glycolysis, the TCA cycle, lipid metabolism, and branched-chain amino acid (BCAA) metabolism, and pointed to the complex pathogenesis mechanisms of APS and VTE. Histidine, 3-hydroxybutyrate, and threonine were shown to be the top three metabolites with the most substantial impact on model predictions, suggesting that these metabolites play a pivotal role in distinguishing among APS, VTE, and HCs. These metabolites might be potential biomarkers to differentiate APS and VTE patients. (AU)

FAPESP's process: 21/07212-0 - Metabolomic and metabonomic analyzes by nuclear magnetic resonance techniques applied in studies of Venous Thrombosis
Grantee:Bruna Maria Manzini
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/14172-6 - Investigation of the pathophysiological aspects and novel therapeutic approaches for thromboembolic disorders
Grantee:Joyce Maria Annichino-Bizzacchi
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 23/02691-2 - Protein exosites, cryptic sites and moonlighting: identification, functional mapping and structural alteration effects
Grantee:Folorunsho Bright Omage
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
Grantee:Marco Aurelio Zezzi Arruda
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health
Grantee:Fernando Barbosa Júnior
Support Opportunities: Research Projects - Thematic Grants