Fourteen weeks of β-alanine supplementation and HIIT did not improve serum BDNF concentrations and Stroop test performance

Author(s)

Mendonca, Paloma Tavares ; Dutra, Yago Medeiros ; Antunes, Barbara M. ; Lira, Fabio ; Zagatto, Alessandro Moura

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. N/A, p. 10-pg., 2025-01-20.

Abstract

This study aimed to investigate whether 14 weeks of beta-alanine supplementation and high-intensity intermittent training improves brain-derived neurotrophic factor concentrations and cognitive aspects related to executive functions assessed by the Stroop test. Thirteen healthy and active men underwent a 4-week supplementation period (beta-alanine: 6.4 g/d or a placebo) followed by 10-week supplementation combined with high-intensity intermittent training, totaling 14 weeks of intervention. Participants underwent a graded exercise test, while the blood samples for brain-derived neurotrophic factor analysis and the Stroop test (cognitive task) were assessed before and after a high-intensity intermittent exercise (10 runs of 1:1 min effort and a pause ratio at 130% of respiratory compensation point). These measurements were performed three times across the study being at baseline, after 4 weeks of supplementation (POST4weeks) and at the end of the 14 weeks of study (POST14weeks). Compared to baseline values, there were no improvements in brain-derived neurotrophic factor concentrations or Stroop test performance with either beta-alanine or high-intensity intermittent training. Lactate peak concentrations in a high-intensity intermittent exercise session also did not differ between groups. However, high-intensity intermittent training did improve some cardiorespiratory parameters (i.e., intensity associated with VO2max p=0.01 and respiratory compensation point, p=0.01). In conclusion, beta-alanine supplementation alone or associated with high-intensity intermittent training did not improve the brain-derived neurotrophic factor concentrations and Stroop test performance in healthy men. (AU)

• FAPESP's process: 21/08479-0 - Time course of neuromuscular recovery after running training session: influence of intensity, hot water immersion and cold water immersion
• Grantee: Yago Medeiros Dutra
• Support Opportunities: Scholarships in Brazil - Doctorate