| Full text | |
| Author(s): |
Marques, Marcelo Borges
;
Posantes, Gabriela Esperanza Maradiaga
;
Goncalves, Luana Stefanie Silvino
;
da Silva, Anderson Tangerino Ferreira
;
Silveira, Heitor Albergoni
;
Chahud, Fernando
;
Leon, Jorge Esquiche
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Head and Neck Pathology; v. 19, n. 1, p. 4-pg., 2025-02-05. |
| Abstract | |
BackgroundNecrotizing sialometaplasia (NSM) is a rare self-limiting inflammatory lesion, with most cases affecting the minor salivary glands, especially those located in the palate (70%). To date, about 261 cases of NSM have been reported. Of them, 7 cases affected the tongue; 37 cases occurred after surgery; and 17 cases showed association with neoplasms.MethodsA 50-year-old male patient was diagnosed with squamous cell carcinoma (SCC) of the tongue. After surgical excision, the tumor diagnosis was well-differentiated SCC with a close surgical margin. Re-excision of the margin was indicated.ResultsMicroscopically, the surgical margin showed neither residual SCC nor epithelial dysplasia. However, it was possible to observe 7 foci containing typical areas of NSM distributed throughout the surgical specimen, which, by immunohistochemistry, revealed a glandular nature with presence of myoepithelial cells.ConclusionWe present here an unusual multifocal NSM affecting the tongue at the site of a prior resection for SCC with close margins, which, to the best of our knowledge, has not been reported to date. (AU) | |
| FAPESP's process: | 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region. |
| Grantee: | Jorge Esquiche León |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 22/12760-9 - Clinicopathological correlation of the immune system, cell differentiation, angiogenesis, lipid metabolism and transcriptionally active HPV in a large series of head and neck squamous cell carcinomas |
| Grantee: | Jorge Esquiche León |
| Support Opportunities: | Regular Research Grants |