Nanomedicine Innovations for Lung Cancer Diagnosis and Therapy

Author(s)

Cardoso, Valeria Maria de Oliveira ; Bistaffa, Maria Julia ; Sterman, Raquel Gonzalez ; Lima, Lorena Leticia Peixoto de ; Toldo, Gustavo Silveira ; Cancino-Bernardi, Juliana ; Zucolotto, Valtencir

• Document type: Journal article
• Source: ACS APPLIED MATERIALS & INTERFACES; v. N/A, p. 24-pg., 2024-12-31.

Abstract

Lung cancer remains a challenge within the realm of oncology. Characterized by late-stage diagnosis and resistance to conventional treatments, the currently available therapeutic strategies encompass surgery, radiotherapy, chemotherapy, immunotherapy, and biological therapy; however, overall patient survival remains suboptimal. Nanotechnology has ushered in a new era by offering innovative nanomaterials with the potential to precisely target cancer cells while sparing healthy tissues. It holds the potential to reshape the landscape of cancer management, offering hope for patients and clinicians. The assessment of these nanotechnologies follows a rigorous evaluation process similar to that applied to chemical drugs, which includes considerations of their pharmacokinetics, pharmacodynamics, toxicology, and clinical effectiveness. However, because of the characteristics of nanoparticles, standard toxicological tests require modifications to accommodate their unique characteristics. Effective therapeutic strategies demand a profound understanding of the disease and consideration of clinical outcomes, physicochemical attributes of nanomaterials, nanobiointeractions, nanotoxicity, and regulatory compliance to ensure patient safety. This review explores the promise of nanomedicine in lung cancer treatment by capitalizing on its unique physicochemical properties. We address the multifaceted challenges of lung cancer and its tumor microenvironment and provide an overview of recent developments in nanoplatforms for early diagnosis and treatment that can enhance patient outcomes and overall quality of life. (AU)

• FAPESP's process: 23/01689-4 - Spectroelectrochemical investigation of sensors and biosensors based on photoactivated plasmonic nanoparticles
• Grantee: Juliana Cancino Bernardi
• Support Opportunities: Regular Research Grants
• FAPESP's process: 23/14785-1 - A study of plasmon-enhanced electrochemical conversion in sensors using scanning electrochemical microscopy and atomic force microscopy
• Grantee: Juliana Cancino Bernardi
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/00124-5 - Functionalization of nanomaterials for cancer therapy
• Grantee: Valtencir Zucolotto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 22/01434-3 - Biomimetic nanoparticles coated with cell membranes as an innovative strategy in lung cancer therapy
• Grantee: Maria Julia Bistaffa
• Support Opportunities: Scholarships in Brazil - Doctorate