Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers

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Lavareze, Luccas ; Kimura, Talita de Carvalho ; Scarini, Joao Figueira ; de Lima-Souza, Reydson Alcides ; Goncalves, Moises Willian Aparecido ; de Sa, Raisa Sales ; Aquino, Iara Goncalves ; Fernandes, Patricia Maria ; Ribeiro, Fernanda Cristina Poscai ; Altemani, Albina ; Mariano, Fernanda Viviane ; Fillmore, Gary Chris ; Abu Egal, Erika Said

• Document type: Journal article
• Source: FRONTIERS IN ONCOLOGY; v. 14, p. 14-pg., 2025-01-07.

Abstract

Erythropoietin-producing hepatocellular (Eph) receptors comprise the largest group of surface receptors and are responsible for cellular signals. Eph/ephrin signaling has been identified to play a role in key cancer development and progression processes, especially in the upper gastrointestinal tract. The Eph/ephrin system has been described as a tumor suppressor in duodenal cancer, while in esophageal, gastric, hepatic, and pancreatic cancer, the system has been related to tumor progression. For their significant role in developing a wide range of malignancies, Eph receptors and their ligands have proven to be an important target for new anticancer therapies. In this review, we present an overview of the literature and highlight evidence supporting the role of the Eph/ephrin system in upper digestive tract cancers. In addition, we discuss molecular findings that represent promising therapeutic targets for these cancers. (AU)

• FAPESP's process: 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
• Grantee: Fernanda Viviane Mariano Brum Corrêa
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 19/09419-0 - Genomic alterations in the malignant transformation of the Pleomorphic Adenoma
• Grantee: João Figueira Scarini
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/06809-2 - Analysis of mass spectrometry in the malignant transformation of the pleomorphic adenoma. correlation of data with gene expression and exome
• Grantee: Reydson Alcides de Lima Souza
• Support Opportunities: Scholarships in Brazil - Master