Development and Application of 3D-Printed Electrochemical Sensors for Ciprofloxacin Detection

Author(s)

Henriques, Brunna F. ; Neumann, Amanda ; Bertolim, Lucas V. ; de Freitas, Rafaela C. ; Silva, Luiz R. G. ; Stefano, Jessica S. ; Janegitz, Bruno C.

• Document type: Journal article
• Source: Electroanalysis; v. 37, n. 1, p. 8-pg., 2025-01-01.

Abstract

The production of electrochemical devices and systems using additive manufacturing technology, particularly three-dimensional (3D) printing, has proven to be highly promising. This work reports the development of 3D-printed electrochemical sensors for the determination of the antibiotic ciprofloxacin (CIP). To achieve this, a lab-made conductive filament composed of carbon black (CB) and polylactic acid (PLA) was produced and utilized in the fabrication of the sensors. Additionally, an electrochemical cell was constructed using a nonconductive filament, resulting in a miniaturized and entirely additively manufactured platform. The characterization of the proposed CB-PLA sensor was carried out using scanning electron microscopy and electrochemical techniques. The proposed sensor has shown a linear range of 1.0-12.5 mu mol L-1, with a sensitivity of 3.77 mu A mu mol-1 L, and limits of detection and quantification of 0.3 and 0.9 mu mol L-1 for CIP, respectively. Regarding the analysis of the samples (tap water and synthetic urine), it was observed recovery values close to 100% for all samples. Thus, the 3D-printed electrochemical device presents itself as a high-potential alternative for CIP drug control, with the possibility of being used in the field and point of care. (AU)

• FAPESP's process: 23/06793-4 - Development of applied multiplex electrochemical systems for detection of biomarkers related to cardiovascular diseases
• Grantee: Bruno Campos Janegitz
• Support Opportunities: Regular Research Grants
• FAPESP's process: 22/08720-1 - Development and application of 3D printed electrochemical sensors for the detection of ciprofloxacin.
• Grantee: Brunna Ferri Henriques
• Support Opportunities: Scholarships in Brazil - Scientific Initiation