Detection and Phylogenetic Analysis of Emerging Human-Associated Gemykibivirus-2 in Molossus molossus Bat From Brazil

Author(s)

Silverio, Bruna Stefanie ; Duro, Rodrigo Lopes Sanz ; de Sousa, Larissa Leao F. ; Guilardi, Mariana Dias ; Cabral-Miranda, Gustavo ; Janini, Luiz Mario Ramos ; Duraes-Carvalho, Ricardo

• Document type: Journal article
• Source: Journal of Medical Virology; v. 97, n. 1, p. 4-pg., 2025-01-01.

Abstract

We detected an emerging human-associated gemykibivirus-2 (HuGkV-2) in rectal swab sample from Molossus molossus bat from Brazil. Phylogenetic analysis further revealed well-supported relationships between our sequence and those associated with human infections. This study underscores the necessity of ongoing monitoring of HuGkV-2 to elucidate potential spillback events, its role in human infections, and its public health implications. (AU)

• FAPESP's process: 19/14526-0 - Development of vaccines against Streptococcus pyogenes and Chikungunya Virus based on virus like particles
• Grantee: Gustavo Cabral de Miranda
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 20/05146-7 - Development of vaccine anti-SARS-CoV-2 based on VLPs
• Grantee: Gustavo Cabral de Miranda
• Support Opportunities: Regular Research Grants
• FAPESP's process: 23/04038-4 - Epidemiological surveillance and principles of viral molecular evolution in the investigation of Coronavirus, Influenza A and Arbovirus in bats from different regions of the State of São Paulo
• Grantee: Bruna Stefanie Silvério
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 21/03684-4 - Bats: epidemiological surveillance, high-resolution phylodynamics, search and design of peptides of biotechnological interest in emergent and reemerging viruses
• Grantee: Ricardo Durães de Carvalho
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 24/09079-3 - Investigation of emerging and reemerging viruses in bat specimens captured in different regions of the State of São Paulo
• Grantee: Rodrigo Lopes Sanz Duro
• Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
• FAPESP's process: 19/01255-9 - Bats: epidemiological surveillance, high-resolution phylodynamics, search and design of peptides of biotechnological interest in emergent and reemerging viruses
• Grantee: Ricardo Durães de Carvalho
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 20/08943-5 - Investigation of the hosts' induced elements in response to the immunisation with ChAdOx1 nCOV-19 vaccine in a Phase III Clinical Trial
• Grantee: Luiz Mário Ramos Janini
• Support Opportunities: Research Projects - Thematic Grants