| Full text | |
| Author(s): Show less - |
Fonseca, Dennyson Leandro M.
;
Jaepel, Maj
;
Gyamfi, Michael Adu
;
Filgueiras, Igor Salerno
;
Baiochi, Gabriela Crispim
;
Ostrinski, Yuri
;
Halpert, Gilad
;
Lavi, Yael Bublil
;
Vojdani, Elroy
;
Silva-Sousa, Thayna
;
Usuda, Julia Nakanishi
;
Santos e Silva, Juan Carlo
;
Freire, Paula P.
;
Nobile, Adriel Leal
;
Adri, Anny Silva
;
Barcelos, Pedro Marcal
;
Correa, Yohan Lucas Goncalves
;
do Vale, Fernando Yuri Nery
;
Lopes, Leticia Oliveira
;
Schmidt, Solveig Lea
;
Wang, Xiaoqing
;
Vahldieck, Carl
;
Fels, Benedikt
;
Schimke, Lena F.
;
Cabral-Miranda, Gustavo
;
Hirata, Mario Hiroyuki
;
Akhan, Taj Ali
;
Yu, Yen-Rei A.
;
Dalmolin, Rodrigo J. S.
;
Amital, Howard
;
Vojdani, Aristo
;
Dias, Haroldo Dutra
;
Nakaya, Helder
;
Ochs, Hans D.
;
Silverberg, Jonathan I.
;
Zimmerman, Jason
;
Zyskind, Israel
;
Rosenberg, Avi Z.
;
Schulze-Forster, Kai
;
Heidecke, Harald
;
Catar, Rusan
;
Moll, Guido
;
Hackel, Alexander
;
Kusche-Vihrog, Kristina
;
Shoenfeld, Yehuda
;
Riemekasten, Gabriela
;
Akbarzadeh, Reza
;
Marques, Alexandre H. C.
;
Cabral-Marques, Otavio
Total Authors: 49
|
| Document type: | Journal article |
| Source: | NPJ SYSTEMS BIOLOGY AND APPLICATIONS; v. 11, n. 1, p. 13-pg., 2025-01-13. |
| Abstract | |
Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes of which remain poorly understood. This study explored the associations between autoantibodies (AABs), particularly those targeting G protein-coupled receptors (GPCRs) and renin-angiotensin system (RAS) molecules, and the clinical manifestations of COVID-19. Using a cross-sectional analysis of 244 individuals, we applied multivariate analysis of variance, principal component analysis, and multinomial regression to examine the relationships between AAB levels and key symptoms. Significant correlations were identified between specific AABs and symptoms such as fever, muscle aches, anosmia, and dysgeusia. Notably, anti-AGTR1 antibodies, which contribute to endothelial glycocalyx (eGC) degradation, a process reversed by losartan, have emerged as strong predictors of core symptoms. AAB levels increased with symptom accumulation, peaking in patients exhibiting all four key symptoms. These findings highlight the role of AABs, particularly anti-AGTR1 antibodies, in determining symptom severity and suggest their involvement in the pathophysiology of COVID-19, including vascular complications. (AU) | |
| FAPESP's process: | 20/16246-2 - Holistic characterization of T cell exhaustion in patients with Zika |
| Grantee: | Dennyson Leandro Mathias da Fonseca |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 19/27139-5 - Application of genomic tools for the study of epidemiological databases |
| Grantee: | Juan Carlo Santos e Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 18/18886-9 - Systemic and integrative analysis of the immune response to Zika and Dengue viral infections |
| Grantee: | Otávio Cabral Marques |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 20/01688-0 - Systemic and integrative analysis of the immune response to Zika and Dengue viral infections |
| Grantee: | Otávio Cabral Marques |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 23/13356-0 - The analysis of neutrophil-activating autoantibodies: a thrombosis perspective |
| Grantee: | Dennyson Leandro Mathias da Fonseca |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |
| FAPESP's process: | 20/07972-1 - Systemic and integrative analysis of T lymphocyte exhaustion mechanisms in patients with COVID-19 |
| Grantee: | Gabriela Crispim Baiocchi |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 23/12268-0 - Integrative systemic characterization of the neuroimmunological interactions of Major Depressive Disorder and its intersection with post-COVID-19 syndrome |
| Grantee: | Anny Silva Adri |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 23/07806-2 - Integrative systems bioinformatics analysis of antiviral immune responses. |
| Grantee: | Igor Salerno Filgueiras |
| Support Opportunities: | Scholarships in Brazil - Technical Training Program - Technical Training |
| FAPESP's process: | 23/06086-6 - SYSTEMIC INTEGRATIVE ANALYSIS OF TUMORS ASSOCIATED WITH HUMAN ONCOVIRUS INFECTIONS |
| Grantee: | Pedro Marçal Barcelos |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 20/09146-1 - Systemic and integrative analysis of molecular mechanisms associated with immunoregulation in patients with COVID-19 |
| Grantee: | Paula Paccielli Freire-Barguil |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 20/07069-0 - Systemic and integrative analysis of T lymphocyte exhaustion mechanisms in patients with COVID-19 |
| Grantee: | Otávio Cabral Marques |
| Support Opportunities: | Regular Research Grants |